Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Autor:	Ran You, Wei Zhou, Yanwei Li, Li Yang
Rok vydání:	2020
Předmět:	0301 basic medicine HIF-1α hypoxia-inducible factor-1α viruses Diminazene aceturate (PubChem CID: 5284544) medicine.disease_cause 0302 clinical medicine Severe acute respiratory syndrome coronavirus 2 Receptor Coronavirus COVID-19 Coronavirus disease 2019 Coronavirus disease 2019 biology hrsACE2 human recombinant soluble ACE2 virus diseases Angiotensin-converting enzyme 2 Prognosis 030220 oncology & carcinogenesis Ang angiotensin Xanthenone (PubChem CID: 7020) Disease Progression PAH pulmonary arterial hypertension Coronavirus Infections hormones hormone substitutes and hormone antagonists Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) SARS-CoV severe acute respiratory syndrome coronavirus Pneumonia Viral Peptidyl-Dipeptidase A ACE2 angiotensin-converting enzyme 2 Resorcinolnaphthalein (PubChem CID: 337218) SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Article DIC disseminated intravascular coagulopathy Betacoronavirus 03 medical and health sciences medicine Humans rACE2 recombinant ACE2 Pandemics Pathological ARDS acute respiratory distress syndrome ComputingMethodologies_COMPUTERGRAPHICS Pharmacology SARS-CoV-2 business.industry COVID-19 RAS renin-angiotensin system biology.organism_classification ARB angiotensin II receptor blocker 030104 developmental biology COPD chronic obstructive pulmonary disease AT2 type II apical surface of epithelial cells Immunology business ACEI ACE inhibitor Homeostasis
Zdroj:	Pharmacological Research
ISSN:	1043-6618
DOI:	10.1016/j.phrs.2020.104833
Popis:	Graphical abstract The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a negative regulator. Recently, ACE2 was identified as the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus that is causing the pandemic of Coronavirus disease 2019 (COVID-19). Since SARS-CoV-2 must bind with ACE2 before entering the host cells in humans, the distribution and expression of ACE2 may be critical for the target organ of the SARS-CoV-2 infection. Moreover, accumulating evidence has demonstrated the implication of ACE2 in the pathological progression in tissue injury and several chronic diseases, ACE2 may also be essential in the progression and clinical outcomes of COVID-19. Therefore, we summarized the expression and activity of ACE2 in various physiological and pathological conditions, and discussed its potential implication in the susceptibility of SARS-CoV-2 infection and the progression and prognosis of COVID-19 patients in the current review.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbeb7f8658ed3dfeb71b3e90566baf1 https://doi.org/10.1016/j.phrs.2020.104833 Zobrazit plný text záznamu Full Text from ScienceDirect