Swimming training can affect intrinsic calcium current characteristics in rat myocardium
| Autor: | Dong Jie Xu, Ke Jiang Cao, Ji Zheng Ma, Shu Shu Zhu, Sen Wang, Jian Gang Zou |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Time Factors Calcium Channels L-Type Physiology Heart Ventricles Physical Exertion Physical exercise Membrane Potentials Muscle hypertrophy Rats Sprague-Dawley Endurance training Physiology (medical) Internal medicine Mod medicine Animals Myocyte Myocytes Cardiac Orthopedics and Sports Medicine Calcium Signaling Swimming Cell Size Ultrasonography business.industry Myocardium Public Health Environmental and Occupational Health Hypertrophy General Medicine Anatomy Adaptation Physiological Rats Intensity (physics) Electrophysiology Cardiology business |
| Zdroj: | European Journal of Applied Physiology. 104:549-555 |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-008-0803-x |
| Popis: | Endurance exercise is widely assumed to improve cardiac function in humans, but the mechanisms involved in such changes are not clearly understood. The purpose of this study is to determine whether training elicits adaptations at the level of the L-type Ca2+ channel. Sprague–Dawley rats performed swimming training at either moderate intensity (MOD) or high intensity (HIGH) during 8 weeks. The trained rats were studied by echocardiography and the whole-cell L-type Ca2+ currents (I Ca,L) characteristics in a single cell were measured by standard whole-cell patch-clamp recording technique. Echocardiography showed that septal and posterior wall thickness in MOD and HIGH increased with the increased LV mass by 43 and 41%, respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink