Predominant Influence of Environmental Determinants on the Persistence and Avidity Maturation of Antibody Responses to Vaccines in Infants

Autor: Tessa Goetghebuer, Paul-Henri Lambert, Maria Pihlgren, Arnaud Marchant, Helen A. Weiss, Martin O. Ota, Susana E. Schlegel-Hauter, Claire-Anne Siegrist, Melanie J. Newport, Hilton Whittle
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Aging
Measles Vaccine
Antibody Affinity
Antibody Formation/genetics
Vaccines/administration & dosage/immunology
Enzyme-Linked Immunosorbent Assay
Biology
ddc:616.07
Environment
Antibodies
Viral
Immunoglobulin G
03 medical and health sciences
0302 clinical medicine
Antibodies
Viral/blood
Antigen
medicine
Tetanus Toxoid
Twins
Dizygotic
Immunology and Allergy
Measles Vaccine/administration & dosage/immunology
Humans
Avidity
030212 general & internal medicine
030304 developmental biology
0303 health sciences
Vaccines
ddc:618
Tetanus
Toxoid
Infant
Antibodies
Bacterial/blood
Twins
Monozygotic
medicine.disease
Antibodies
Bacterial
3. Good health
Infectious Diseases
Immunization
Immunoglobulin G/blood
Immunology
Tetanus Toxoid/administration & dosage/immunology
Antibody Formation
biology.protein
Gambia
Measles vaccine
Antibody
Zdroj: The Journal of Infectious Diseases, Vol. 193, No 11 (2006) pp. 1598-605
ISSN: 0022-1899
Popis: BACKGROUND Immune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses. METHODS Antibody responses to tetanus toxoid (TT), measles vaccines, and environmental antigens (total IgG levels) were measured in 210 Gambian twin pairs recruited at birth. Intrapair correlations for monozygous and dizygous pairs were compared to estimate the environmental and genetic components of variations in response. RESULTS In contrast to antibody responses measured in infants at age 5 months, 1 month after immunization, no significant contribution of genetic factors to anti-TT antibody and total IgG levels was detected at age 12 months. Genetic factors controlled measles antibody responses in 12-month-old infants, which indicates that the increasing influence of environmental determinants on anti-TT responses was not related to the older age of the children but, rather, to the time elapsed since immunization. Environmental factors also predominantly controlled affinity maturation and the production of high-avidity antibodies to TT. CONCLUSIONS Genetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturation.
Databáze: OpenAIRE
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