Outcome of intracytoplasmic sperm injection after preinstillation of a gonadotropin releasing hormone agonist in the uterine cavity just before embryo transfer
| Autor: | Halis Özdemir, Pinar Caglar Aytac, Esra Bulgan Kilicdag, Bulent Haydardedeoglu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.drug_class medicine.medical_treatment lcsh:Medicine Gonadotropin releasing hormone agonist lcsh:Gynecology and obstetrics Intracytoplasmic sperm injection Miscarriage Andrology 03 medical and health sciences 0302 clinical medicine In vitro fertilization Gonadotropin-releasing hormone agonist Medicine Clinical Investigation lcsh:RG1-991 Pregnancy 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry lcsh:R Obstetrics and Gynecology Embryo transfer medicine.disease Uterine cavity Pregnancy rate 030104 developmental biology medicine.anatomical_structure business |
| Zdroj: | Turkish Journal of Obstetrics and Gynecology Turkish Journal of Obstetrics and Gynecology, Vol 14, Iss 2, Pp 76-81 (2017) |
| ISSN: | 1307-699X |
| Popis: | Objective: To evaluate the effects of a gonadotropin releasing hormone agonist (GnRHa) injection prior to embryo transfer on implantation and pregnancy rate. Materials and Methods: We performed a retrospective analysis of patients undergoing in vitro fertilization (IVF) therapy with and without GnRHa preinstallation into the uterine cavity just before embryo transfer between January 2012 and March 2013 in a single IVF center of a university hospital. Patients were evaluated based upon implantation, pregnancy, live birth, and miscarriage rates. Results: GnRHa was injected into the uterine cavity of 108 patients prior to embryo transfer which were regarded as study group. One thousand forty-seven patients who were not injected GnRHa were regarded as the control group. Pregnancy rates were 44.4% and 41.7% in the GnRHa and control groups, respectively. Live birth rates were 27.8% and 26.1%, miscarriage rates were 15.7% and 15.7%, and implantation rates were 31% and 30%, respectively and there were no difference between groups statistically (p>0.05). Conclusion: No statistically significant differences in implantation, pregnancy, live birth, or miscarriage rates were observed in patients treated with GnRHa prior to embryo transfer, relative to the controls. Therefore, GnRHa injection into the uterine cavity prior to embryo transfer is not recommended as a means of increasing implantation or pregnancy rates in IVF. However, prospective randomized controlled studies are needed to clarify the effect of GnRHa instillation in the uterine cavity for embryo implantation in IVF. |
| Databáze: | OpenAIRE |
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