The prognostic factors of primary colorectal sarcoma and the clinical outcomes of negative lymph node dissection
| Autor: | Xiao Chen, Zhen Huang, Zhiyu Li, Zhewen Wei, Jianjun Zhao, Yefan Zhang, Xinyu Bi, Rui Mao, Jianguo Zhou, Jianqiang Cai, Hong Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Proportional hazards model business.industry Hazard ratio General Medicine 030230 surgery Colorectal Sarcoma medicine.disease Malignancy Primary tumor Confidence interval 03 medical and health sciences Dissection 0302 clinical medicine Interquartile range 030220 oncology & carcinogenesis Internal medicine medicine Original Article business |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5839 |
| Popis: | BACKGROUND: Primary colorectal sarcoma is an extremely rare malignancy that is associated with poor patient outcomes. The aim of this study was to identify the prognostic factors of primary colorectal sarcoma and evaluate the clinical outcomes associated with these prognostic factors. METHODS: Between January 1, 2000 and December 31, 2016, the clinical data of 315 patients with primary colorectal sarcoma were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Cancer-specific survival (CSS) was analyzed by the Kaplan-Meier method and by log-rank test. The prognostic factors were identified by univariate and multivariate Cox regression analysis and hazard ratio (HR) and 95% confidence interval (CI) of covariates were also estimated. The optimal cutoff value for NLN count at dissection was identified using X-tile software and validated by univariate Cox regression analysis. RESULTS: Of the 315 patients with primary colorectal sarcoma identified, 88.6% received surgery. The median follow-up time was 34 months with an interquartile range (IQR) of 9–79 months. The 5-year rate of CSS was 76.73% and 27.8% for the surgery group and the non-surgery group, respectively (P80 years old) and poor CSS (HR 1.964; 95% CI: 1.005–3.839; P=0.048). There were also significant correlations between colonic tumors and poor CSS (HR 2.903; 95% CI: 1.348–6.250; P=0.006) and grade IV tumors and poor CSS (HR 3.431; 95% CI: 1.725–6.823; P |
| Databáze: | OpenAIRE |
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