Acute oral toxicity of various drugs in newborn rats after treatment of the dam during gestation
| Autor: | Steven Carson, Richard E. Goldhamer, Myron S. Weinberg |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Dextroamphetamine
macromolecular substances Pharmacology Toxicology chemistry.chemical_compound Oral administration Pregnancy Tannic acid Medicine Animals Meprobamate Maternal-Fetal Exchange Gastrointestinal tract Fetus biology Aspirin business.industry Enzyme assay Rats chemistry Animals Newborn Liver Phenobarbital Toxicity biology.protein Gestation Pregnancy Animal Female business Tannins After treatment |
| Zdroj: | Toxicology and applied pharmacology. 9(2) |
| ISSN: | 0041-008X |
| Popis: | Effects of the oral administration to pregnant rats of several commonly used drugs on toxicity to newborn pups were studied. In general, toxicity to the newborn was reduced only when the doses were administered after day 14 of gestation. No effects were seen with tannic acid, which appears to exert a local action on the gastrointestinal tract. Some increase in soluble enzyme activity in the liver of rat fetuses occurred following treatment of the gestating dam. |
| Databáze: | OpenAIRE |
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