Asymmetric Cortical Vessel Sign Indicates Hemodynamic Deficits in Adult Patients with Moyamoya Disease
| Autor: | Shan Tikun, You Chao, Liu Yi, Qiu Qiongqiong, Xia Chunchao, Qian Weiqiang, Zhang Jinge |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty viruses Ischemia Hemodynamics Neuroimaging Perfusion scanning Brain Ischemia Hemoglobins Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Prospective Studies Moyamoya disease skin and connective tissue diseases Cerebral Revascularization business.industry virus diseases medicine.disease Magnetic Resonance Imaging Oxygen Cerebral blood flow Bypass surgery Cerebrovascular Circulation 030220 oncology & carcinogenesis Susceptibility weighted imaging Cardiology Female Surgery Neurology (clinical) Moyamoya Disease Tomography X-Ray Computed business Perfusion 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 127:e137-e141 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2019.02.187 |
| Popis: | Asymmetric cortical vessel sign (ACVS) on susceptibility-weighted imaging (SWI) indicates elevated concentration of deoxyhemoglobin and elevated oxygen extraction fraction in patients with cerebral ischemia. This study aimed to clarify whether ACVS is associated with impaired hemodynamics and hyperperfusion syndrome in patients with moyamoya disease (MMD).Consecutive adult patients with MMD were enrolled. ACVS data on SWI and perfusion data using dynamic perfusion computed tomography were obtained and evaluated preoperatively and on postoperative days 2 and 180.A total of 24 patients with MMD were enrolled. Of 11 (45.83%) patients showing positive ACVS before surgery, 8 turned negative on postoperative day 2 and 9 showed absence of ACVS 180 days after surgery. Regions of interest showing positive ACVS had lower cerebral blood flow (CBF, P0.001), increased cerebral blood volume (P = 0.021), prolonged time to peak (P0.001), and mean transit time (P = 0.009). No patients with hemorrhagic symptoms showed positive ACVS(P = 0.041) and patients with positive ACVS showed more increase in CBF (P0.004).In patients with MMD, ACVS on SWI indicates severe impairment in hemodynamics and is associated with more increase in CBF after bypass surgery. Hence, ACVS on SWI might be considered as a neuroimaging marker for the evaluation of hemodynamics in patients with MMD. |
| Databáze: | OpenAIRE |
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