The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

Autor: Dafydd R. Owen, Brandon J. Turunen, Robert E. Futrell, Caitlin E. Mills, Daniel Ebner, Christian Fischer, Mathias Frederiksen, Santiago Vilar, Kumar Singh Saikatendu, Stephanie B Hatch, Christopher R. M. Asquith, William J. Zuercher, Timothy M. Willson, Alfredo Picado, Nathanael S. Gray, David M. Andrews, Hassan Al-Ali, Martin Schröder, Mariana Tellechea, Jinhua Wang, Michael Michaelides, Alison D. Axtman, Ulrich Lücking, David H. Drewry, Carrow I. Wells, Alexandra Stolz, Stefan Knapp, Susanne Müller, Peter Ettmayer, Ivan Dikic
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Open science
druggable genome
kinase inhibitor
Phenotypic screening
Computational biology
Protein Serine-Threonine Kinases
Biology
Article
Catalysis
drug discovery
Small Molecule Libraries
Inorganic Chemistry
Set (abstract data type)
lcsh:Chemistry
Structure-Activity Relationship
03 medical and health sciences
0302 clinical medicine
Humans
ddc:610
Physical and Theoretical Chemistry
Protein kinase A
Protein Kinase Inhibitors
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
030304 developmental biology
0303 health sciences
chemogenomic set
understudied kinase
Kinase
Drug discovery
Organic Chemistry
phenotypic screening
protein kinase
General Medicine
Small molecule
3. Good health
Computer Science Applications
small molecules
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
KCGS
Identification (biology)
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 566, p 566 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 2
ISSN: 1661-6596
1422-0067
Popis: We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
Databáze: OpenAIRE
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