Is metastatic lymph node ratio superior to the number of metastatic lymph nodes to assess outcome and survival of gastric cancer?
| Autor: | Umut Kefeli, Ahmet Bilici, Taflan Salepci, Alpaslan Mayadagli, Mahmut Gumus, Bala Basak Oven Ustaalioglu, Berkant Sonmez, Metin Kement, Mesut Seker, Emre Yildirim, Burcak Yilmaz |
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| Přispěvatelé: | ŞEKER, MESUT, YILDIRIM, ELİF ÖZLEM, SÖNMEZ, BERKANT, MAYADAĞLI, ALPASLAN |
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Turkey Lymph node metastasis Sensitivity and Specificity Stomach Neoplasms Internal medicine Outcome Assessment Health Care medicine Prevalence Humans Lymph node Survival rate Survival analysis Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Proportional hazards model business.industry Sentinel Lymph Node Biopsy Cancer Reproducibility of Results Retrospective cohort study Hematology Middle Aged medicine.disease Survival Analysis humanities body regions Survival Rate medicine.anatomical_structure Lymphatic Metastasis Female Lymph Lymph Nodes business |
| Zdroj: | Onkologie. 33(3) |
| ISSN: | 1423-0240 |
| Popis: | The aim of this study was to determine the prognostic value of metastatic lymph node ratio (n ratio).We retrospectively analyzed 202 patients who had undergone curative gastrectomy. The prognostic factors including UICC/AJCC TNM classification and n ratio were evaluated by univariate and multivariate analysis.The n ratio was significantly higher in patients with gastric tumors with undifferentiated histology, greater size, lymphatic vessel, blood vessel and perineural invasion (PNI), and advanced stage. Multivariate analysis indicated that n ratio and pN classification were independent prognostic factors, as were age, tumor size, Borrmann classification, PNI, and tumor differentiation. The receiver operating characteristics (ROC) analysis showed that the sensitivity and the specificity of the presence of lymph node metastasis with 16 lymph nodes resected - which was required to assess the presence of lymph node involvement - were 67.1 and 66.6%, respectively. Three-year overall survival (OS) rates and the median OS time were lower in patients with16 lymph nodes resected compared to the patients who had16 lymph nodes resected (p = 0.04).Our results showed that n ratio and pN classification were independent prognostic indicators for OS of patients with radically resected gastric cancer, but the superiority of n ratio to pN stage could not be proved. |
| Databáze: | OpenAIRE |
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