Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens
| Autor: | W.I. Silva, Hugo F. Miranda, W.W. Wolstenholme, N. Cuevas |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pharmacology
Male Chemistry Vas deferens Scopolamine Derivatives Parasympatholytics Muscle Smooth Rats Inbred Strains Pirenzepine N-Methylscopolamine Receptors Muscarinic Rats medicine.anatomical_structure Vas Deferens Competitive antagonist Muscarinic acetylcholine receptor medicine Animals Antagonism medicine.drug Methyl scopolamine Acetylcholine receptor Muscle Contraction |
| Zdroj: | General pharmacology. 19(3) |
| ISSN: | 0306-3623 |
| Popis: | 1. 1. The effects of pirenzepine and N -methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. 2. Pirenzepine was inactive at the M 2 -ACh receptor. 3. 3. N -methyl-scopolamine was a competitive antagonist (p A 2 = 8.76) at M 2 -ACh receptor, alone or in the presence of pirenzepine. 4. 4. Pirenzepine and N -methyl-scopolamine were both non-competitive antagonists at M 1 -ACh receptor. 5. 5. The mixture of pirenzepine and N -methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M 1 -ACh receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|