Postmortem histopathology of electroencephalography and evoked potentials in postanoxic coma
| Autor: | Albertus Beishuizen, Casper Jansen, Tim M.J. Beernink, Frank H. Bosch, Rob Koot, Jeannette Hofmeijer, Marleen C. Tjepkema-Cloostermans, Michel J.A.M. van Putten |
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| Přispěvatelé: | Clinical Neurophysiology |
| Rok vydání: | 2019 |
| Předmět: |
Male
Cerebellum Postanoxic coma Encephalopathy UT-Hybrid-D Hippocampus Brain damage Prognostication Emergency Nursing Electroencephalography Evoked Potentials Somatosensory Cortex (anatomy) medicine Humans Prospective Studies EEG Coma Aged medicine.diagnostic_test business.industry Postmortem histopathology Middle Aged medicine.disease SSEP Heart Arrest Burst suppression medicine.anatomical_structure lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Somatosensory evoked potential Hypoxia-Ischemia Brain Emergency Medicine Female Autopsy medicine.symptom Cardiology and Cardiovascular Medicine business Neuroscience |
| Zdroj: | Resuscitation, 134, pp. 26-32 Resuscitation, 134, 26-32 Resuscitation, 134, 26-32. Elsevier |
| ISSN: | 0300-9572 |
| Popis: | Contains fulltext : 215687.pdf (Publisher’s version ) (Closed access) Early EEG patterns and SSEP responses are associated with neurological recovery of comatose patients with postanoxic encephalopathy after cardiac arrest. However, the nature and distribution of brain damage underlying the characteristic EEG and SSEP patterns are unknown. We relate EEG and SSEP findings with results from histological analyses of the brains of eleven non-survivors. With restoration towards continuous rhythms within 24h after cardiac arrest, no signs of structural neuronal damage were observed. Absent SSEP responses were always accompanied by thalamic damage. Pathological burst suppression patterns were associated with a variable degree of neuronal damage to cortex, cerebellum and hippocampus. In patients with additional thalamic involvement, burst-suppression with identical bursts was observed, a characteristic EEG pattern presumably reflecting residual activity from a relatively isolated and severely compromised cortex. |
| Databáze: | OpenAIRE |
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