Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management
| Autor: | Murali Appukuttan, Chhagan Bihari, Nikhil Agrawal, Tushar Kanti Chattopadhyay, Asit Arora, Shyam Sunder Mahansaria |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Ampulla of Vater medicine.medical_specialty Mixed adenoneuroendocrine carcinoma medicine.medical_treatment Common Bile Duct Neoplasms Mixed type Adenocarcinoma Gastroenterology World health Pancreaticoduodenectomy Pathology and Forensic Medicine 03 medical and health sciences Rare Diseases 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Retrospective Studies business.industry Large cell Histology Middle Aged Prognosis medicine.disease Survival Analysis Carcinoma Neuroendocrine Mixed Tumor Malignant Chemotherapy Adjuvant 030220 oncology & carcinogenesis Pancreatitis Female 030211 gastroenterology & hepatology Surgery Histopathology Neoplasm Grading Neoplasm Recurrence Local Anatomy Tomography X-Ray Computed business |
| Zdroj: | International Journal of Surgical Pathology. 25:585-591 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/1066896917712454 |
| Popis: | Introduction. Mixed adenoneuroendocrine carcinoma (MANEC) has recently been defined by the World Health Organization in 2010. These are rare tumors and MANECs of ampullary region are even rarer. Only 19 cases have been reported in literature. We present 3 cases; the largest series, second case of amphicrine tumor and first case associated with chronic pancreatitis. Methods. Retrospective review of 3 patients who were diagnosed to have ampullary MANEC. Results. All 3 patients were diagnosed preoperatively as neuroendocrine carcinoma and underwent margin negative pancreaticoduodenectomy. The histopathology revealed MANECs of small cell, mixed type in 2 patients and large cell, amphicrine type in 1 patient. The neuroendocrine component was grade 3 in all, the tumor was T3 in 2 and T2 in 1 and all had nodal metastases. Two patients received adjuvant chemotherapy and 2 of them had recurrence at 13 and 16 months. The median survival was 15 months. Conclusion. Ampullary MANECs are rare tumors. They are diagnosed on histopathologic examination of the resected specimen. Clinical presentation, management, and prognosis is similar to ampullary adenocarcinoma in literature. |
| Databáze: | OpenAIRE |
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