Different corticostriatal patterns of L-DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine

Autor:	Arvid Carlsson, Nicholas Waters, Susanna Waters, Joakim Tedroff, Leif Lindström, O. Gefvert
Rok vydání:	2003
Předmět:	Adult Psychosis medicine.medical_specialty medicine.medical_treatment Dopamine Agents Pharmacology Levodopa Arts and Humanities (miscellaneous) Developmental and Educational Psychology medicine Humans In patient Least-Squares Analysis Antipsychotic Psychiatry Clozapine General Psychology Principal Component Analysis medicine.diagnostic_test Dopaminergic Brain General Medicine medicine.disease Mechanism of action Schizophrenia Positron emission tomography Haloperidol medicine.symptom Psychology medicine.drug Antipsychotic Agents Tomography Emission-Computed
Zdroj:	Scandinavian journal of psychology. 44(3)
ISSN:	0036-5564
Popis:	Positron emission tomography (PET) has been shown to be of great importance in elucidating the mechanism of action of antipsychotic drugs. In psychotic patients L-[11C]DOPA PET has been used to demonstrate some differences in dopaminergic activity compared with that in healthy volunteers. Ten healthy volunteers were investigated with PET and L-[11C]DOPA. Ten drug-free patients with psychosis, nine stable schizophrenics treated with clozapine, and nine stable patients treated with classical antipsychotics were also investigated with L-[11C]DOPA. Principal-component analysis was employed for the analysis of L-[11C]DOPA Ki values across a number of corticostriatal brain regions. These data revealed a significant three-component model with clear-cut separation between healthy controls and patients with unmedicated schizophrenia. Stable optimal treatment with either classical neuroleptics or clozapine partially, albeit differentially, reversed the aberrant patterns seen in drug-free schizophrenia. It can thus be concluded that schizophrenia is associated with abnormal patterns of L-[11C]DOPA utilization in corticostriatal systems. Treatment with clozapine or classical neuroleptics induces partial, albeit differential, normalization of the abnormal patterns seen in untreated schizophrenia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb0bf48ab939ce0fbae01a8e923e85b https://pubmed.ncbi.nlm.nih.gov/12914593 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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