Association between central retinal thickness and low luminance visual acuity in early age-related macular degeneration
| Autor: | Francisco Javier Hurtado-Ceña, María Jesús Pérez-Carrasco, Inés Contreras, María C. Puell |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Mesopic vision Vision Disorders Visual Acuity Luminance Retina Macular Degeneration 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Age related Ophthalmology Optometría Humans Medicine business.industry Retinal General Medicine Macular degeneration medicine.disease eye diseases Cross-Sectional Studies medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Oftalmología sense organs medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery Photopic vision |
| Zdroj: | E-Prints Complutense. Archivo Institucional de la UCM instname E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/1120672120968740 |
| Popis: | Purpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|