Maternal diabetes-related malformations in Utah: A population study of birth prevalence 2001-2016
| Autor: | Amy Nance, Jane Johnson, John C. Carey, Michelle A Silver, Matthew M Orbain, Lynn Martinez, Marsha Leen-Mitchell, Alfred N. Romeo |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Embryology medicine.medical_specialty Health Toxicology and Mutagenesis Population Maternal diabetes 030105 genetics & heredity Toxicology 03 medical and health sciences Pregnancy Utah Epidemiology Diabetic Embryopathy Prevalence Medicine Humans education education.field_of_study business.industry Obstetrics Congenital malformations Diabetes Gestational 030104 developmental biology Increased risk Research Design Pediatrics Perinatology and Child Health Pregestational Diabetes Population study Female business Developmental Biology |
| Zdroj: | Birth defects researchREFERENCES. 113(2) |
| ISSN: | 2472-1727 |
| Popis: | Maternal pregestational diabetes mellitus is associated with an increased risk for congenital malformations of about 2-4 times the background risk. Notably, the types and patterns of congenital malformations associated with maternal diabetes are nonrandom, with a well-established increased risk for specific classes of malformations, especially of the heart, central nervous system, and skeleton. While the increased risk in clinical and epidemiological studies is well documented in the literature, a precise estimate of overall birth prevalence of these specific congenital malformations among women with maternal pregestational diabetes, is lacking. The purpose of this study was to determine total prevalence of structural malformations associated with maternal pregestational diabetes mellitus in a population-based study. We identified infants with specific birth defects whose mother had pregestational diabetes mellitus in the Utah Birth Defect Network (UBDN), an active birth defects surveillance program that registers the occurrence of selected structural defects in the state of Utah. We defined specific maternal diabetes-related malformations based on epidemiologic and clinical studies in the literature. Of the 825,138 recorded Utah births between 2001 and 2016, a total of 91 cases were identified as likely having diabetic embryopathy within UBDN data. The prevalence of diabetes-related congenital malformation cases was calculated per year; the overall prevalence of diabetes-related malformations 2001-2016 was 1.1 per 10,000 births in Utah (95% CI, 0.9-1.3). Knowledge of the overall prevalence of diabetes-related malformations is important in predicting the number of cases that are potentially prevented with the implementation of programs to foster preconceptional management of maternal pregestational diabetes. |
| Databáze: | OpenAIRE |
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