Atypical VZV Retinitis in a Patient with Good Syndrome
| Autor: | Miki Honda, Takenori Inomata, Akira Murakami |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Herpesvirus 3 Human Thymoma viruses medicine.medical_treatment Congenital cytomegalovirus infection Visual Acuity Retinitis Progressive outer retinal necrosis Acyclovir Eye Infections Viral medicine.disease_cause Antiviral Agents Polymerase Chain Reaction Aqueous Humor 03 medical and health sciences 0302 clinical medicine Agammaglobulinemia medicine Immunology and Allergy Humans Fluorescein Angiography Sinusitis business.industry Varicella zoster virus virus diseases Valine Thymus Neoplasms Middle Aged medicine.disease medicine.infectious_disease CD4 Lymphocyte Count Thymectomy Ophthalmology Herpes simplex virus 030220 oncology & carcinogenesis Valacyclovir Immunology DNA Viral 030221 ophthalmology & optometry Herpes Zoster Ophthalmicus business |
| Zdroj: | Ocular immunology and inflammation. 26(2) |
| ISSN: | 1744-5078 |
| Popis: | Purpose: To describe atypical varicella zoster virus (VZV) retinitis in a patient with Good syndrome.Methods: A 63-year-old patient with Good syndrome presented with bilateral necrotizing retinitis starting from the posterior pole. He had a history of thymoma status post thymectomy 4 years previously, left-sided sinusitis, and recent pulmonary aspergillosis. Qualitative PCR was performed on aqueous fluid.Results: Immunological investigations revealed reduced levels of CD4+ T cells and immunoglobulins. Qualitative PCR was positive for VZV and negative for cytomegalovirus, herpes simplex virus (HSV)-1, and HSV-2. The patient was treated with oral valacyclovir and three courses of immunoglobulin supplementation. The atypical retinitis showed improvement after therapy.Conclusion: Good syndrome should be considered in a patient with opportunistic infections and history of thymoma in the absence of human immunodeficiency virus. Atypical retinitis can occur in patients with Good syndrome and quantitative... |
| Databáze: | OpenAIRE |
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