International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents

Autor: Dave Evans, D.I. Boomsma, Martin D. Tobin, Germaine C. Verwoert, Ollie Raitakari, Beate St Pourcain, Debbie A Lawlor, Mika Kähönen, Jorma Viikari, Laurent Briollais, John P. Newnham, Cornelia M. van Duijn, Marcella Marinelli, Leo-Pekka Lyytikäinen, Nicholas G. Martin, Fernando Rivadeneira, Laura D Howe, Craig E. Pennell, Penelope A. Lind, Matthew W. Gillman, Lyle J. Palmer, Elisabeth Thiering, André G. Uitterlinden, Marjo Riita Jarvelin, Grant W. Montgomery, Vincent W. V. Jaddoe, Albert Hofman, John Whitfield, Terho Lehtimäki, Jesus Vioque, H. Rob Taal, Lawrence J. Beilin, P. Parmar, Jouke-Jan Hottenga, Margie Wright, Joachim Heinrich, Ville Aalto, Nicholas J. Timpson
Přispěvatelé: Biological Psychology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, EMGO+ - Mental Health, Epidemiology, Pediatrics, Internal Medicine, Erasmus MC other
Jazyk: němčina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Candidate gene
Genome Wide Association Study
Blood Pressure
Children
Genetic Epidemiology
Hypertension
Prehypertension
Genome-wide association study
Polymorphism (computer science)
Risk Factors
Medicine
Child
Genetics (clinical)
Genetics
Molecular Epidemiology
Age Factors
Single Nucleotide
Phenotype
Child
Preschool
Hypertension/diagnosis
Female
Cardiology and Cardiovascular Medicine
Integrin alpha Chains
Genetic Markers
Adolescent
Blood Pressure/genetics
Integrin alpha Chains/genetics
Polymorphism
Single Nucleotide
Risk Assessment
White People
Article
03 medical and health sciences
Young Adult
Prepuberty
Humans
Genetic Predisposition to Disease
Polymorphism
Preschool
Molecular epidemiology
business.industry
ta1184
ta3121
030104 developmental biology
Genetic epidemiology
Genetic marker
Genetic Loci
business
Genome-Wide Association Study
Whites/genetics
Zdroj: Circ. Cardiovasc. Genet. 9, 266-278 (2016)
Circulation. Cardiovascular genetics, 9(3), 266-278. American Heart Association
Circulation-cardiovascular genetics, 9(3), 266-+. Lippincott Williams & Wilkins
Early Genetics and Lifecourse Epidemiology Consortium 2016, ' International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents ', Circulation. Cardiovascular genetics, vol. 9, no. 3, pp. 266-278 . https://doi.org/10.1161/CIRCGENETICS.115.001190
ISSN: 1942-325X
DOI: 10.1161/CIRCGENETICS.115.001190
Popis: Background— Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. Methods and Results— Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4–7 years), puberty (8–12 years), and postpuberty (13–20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 ( ITGA11 , located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5′-C-phosphate-G-3′ methylation site) during prepuberty ( P =2.86×10 –8 ) and rs872256 during puberty ( P =8.67×10 –9 ). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P –3 . Using a P value threshold of –3 , we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms. Conclusions— Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
Databáze: OpenAIRE
Externí odkaz: