Imbalance in gut microbes from babies born to obese mothers increases gut permeability and myeloid cell adaptations that provoke obesity and NAFLD
| Autor: | Jacob E. Friedman, Taylor K. Soderborg |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0209 industrial biotechnology
obesity pediatrics immune education microbiome Inflammation 02 engineering and technology macrophage Gut flora Biochemistry Genetics and Molecular Biology (miscellaneous) Microbiology Applied Microbiology and Biotechnology digestive system Article Proinflammatory cytokine 020901 industrial engineering & automation Immune system Virology NAFLD parasitic diseases 0202 electrical engineering electronic engineering information engineering Genetics medicine Microbiome Molecular Biology lcsh:QH301-705.5 biology business.industry 020208 electrical & electronic engineering Fatty liver Cell Biology medicine.disease biology.organism_classification Microreview 3. Good health developmental origins of disease lcsh:Biology (General) Immunology Parasitology Steatohepatitis medicine.symptom business Dysbiosis |
| Zdroj: | Nature Communications Microbial Cell, Vol 6, Iss 1, Pp 102-104 (2018) Microbial Cell |
| ISSN: | 2311-2638 |
| Popis: | Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant gut by microbes plays a critical role in establishing immunity and metabolic function. Here, we compare germ-free mice colonized with stool microbes (MB) from 2-week-old infants born to obese (Inf-ObMB) or normal-weight (Inf-NWMB) mothers. Inf-ObMB-colonized mice demonstrate increased hepatic gene expression for endoplasmic reticulum stress and innate immunity together with histological signs of periportal inflammation, a histological pattern more commonly reported in pediatric cases of NAFLD. Inf-ObMB mice show increased intestinal permeability, reduced macrophage phagocytosis, and dampened cytokine production suggestive of impaired macrophage function. Furthermore, exposure to a Western-style diet in Inf-ObMB mice promotes excess weight gain and accelerates NAFLD. Overall, these results provide functional evidence supporting a causative role of maternal obesity-associated infant dysbiosis in childhood obesity and NAFLD. Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-induced metabolic disease in germ-free mice. |
| Databáze: | OpenAIRE |
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