Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat
| Autor: | Michael H. Mesches, A.-Ch. Granholm, Paula C. Bickford, Sonya Juthberg, Gregory M. Rose, Michael Browning, Dave Albeck |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Aging Hippocampus Endogeny Internal medicine Nerve Growth Factor medicine Distribution (pharmacology) Animals Cholinergic neuron Molecular Biology Basal forebrain General Neuroscience Brain Rats Inbred F344 Rats Endocrinology Nerve growth factor nervous system Axoplasmic transport Neurology (clinical) Psychology Cognition Disorders Neuroscience Aged rat Developmental Biology |
| Zdroj: | Brain research. 967(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Alzheimer's disease and normal aging may impair retrograde transport of nerve growth factor (NGF) from cortical areas to basal forebrain cholinergic neurons. We demonstrate a relationship between performance in a spatial reference memory task and NGF distribution in the aged rat brain. In addition, exogenous NGF restored endogenous NGF distribution in cognitively impaired aged rats. These data suggest that NGF administration restores utilization of endogenous growth factor in the brain of cognitively impaired aged rats. |
| Databáze: | OpenAIRE |
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