Neuregulin-1 (NRG-1) and its susceptibility to schizophrenia: a case-control study and meta-analysis
| Autor: | Shiau Foon Tee, Chee Yen Choong, Pek Yee Tang, Shen-Yang Lim, Tze Jen Chow, Han Chern Loh, Hoi-Sen Yong |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Schizophrenia (object-oriented programming) Neuregulin-1 behavioral disciplines and activities Polymorphism Single Nucleotide White People Malaysian population Asian People Internal medicine mental disorders medicine Humans Genetic Predisposition to Disease Neuregulin 1 Psychiatry Biological Psychiatry Malay biology Case-control study language.human_language Psychiatry and Mental health Meta-analysis Case-Control Studies language biology.protein Schizophrenia Female Psychology |
| Zdroj: | Psychiatry research. 208(2) |
| ISSN: | 1872-7123 |
| Popis: | Neuregulin-1 is widely investigated due to its hypothesised association with schizophrenia. Single-nucleotide polymorphisms rs764059, rs2954041 and rs3924999 were investigated (417 patients with schizophrenia and 429 controls). We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic. |
| Databáze: | OpenAIRE |
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