Milk fat globule membrane attenuates high fat diet-induced neuropathological changes in obese Ldlr−/−.Leiden mice
| Autor: | Lonneke van der Logt, Vivienne Verweij, Maximilian Wiesmann, Janna A. van Diepen, Martine C. Morrison, Amanda J. Kiliaan, Gabriele Gross, Nicole Worms, Robert Kleemann, Bram Geenen, Ilse A.C. Arnoldussen, Natàlia Pujol Gualdo, Marijke Voskuilen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty Whey protein Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] Endocrinology Diabetes and Metabolism Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Medicine (miscellaneous) Hippocampus Mice Obese Hippocampal formation Diet High-Fat White matter chemistry.chemical_compound Mice Internal medicine medicine Animals Life Science Obesity Neuroinflammation Neuropathology Glycoproteins Nutrition and Dietetics Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] Lipid Droplets medicine.disease Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Low-density lipoprotein LDL receptor Glycolipids |
| Zdroj: | International Journal of Obesity, 46(2), 342-349 International Journal of Obesity, 46, 342-349 International Journal of Obesity, 46(2), 342-349. SPRINGERNATURE International Journal of Obesity 46 (2022) 2 International Journal of Obesity, 46, 2, pp. 342-349 |
| ISSN: | 0307-0565 |
| Popis: | Item does not contain fulltext BACKGROUND: Milk-fat globule membrane (MFGM) is a complex structure secreted by the mammary gland and present in mammalian milk. MFGM contains lipids and glycoproteins as well as gangliosides, which may be involved in myelination processes. Notably, myelination and thereby white matter integrity are often altered in obesity. Furthermore, MFGM interventions showed beneficial effects in obesity by affecting inflammatory processes and the microbiome. In this study, we investigated the impact of a dietary MFGM intervention on fat storage, neuroinflammatory processes and myelination in a rodent model of high fat diet (HFD)-induced obesity. METHODS: 12-week-old male low density lipoprotein receptor-deficient Leiden mice were exposed to a HFD, a HFD enriched with 3% whey protein lipid concentrate (WPC) high in MFGM components, or a low fat diet. The impact of MFGM supplementation during 24-weeks of HFD-feeding was examined over time by analyzing body weight and fat storage, assessing cognitive tasks and MRI scanning, analyzing myelinization with polarized light imaging and examining neuroinflammation using immunohistochemistry. RESULTS: We found in this study that 24 weeks of HFD-feeding induced excessive fat storage, increased systolic blood pressure, altered white matter integrity, decreased functional connectivity, induced neuroinflammation and impaired spatial memory. Notably, supplementation with 3% WPC high in MFGM components restored HFD-induced neuroinflammation and attenuated the reduction in hippocampal-dependent spatial memory and hippocampal functional connectivity. CONCLUSIONS: We showed that supplementation with WPC high in MFGM components beneficially contributed to hippocampal-dependent spatial memory, functional connectivity in the hippocampus and anti-inflammatory processes in HFD-induced obesity in rodents. Current knowledge regarding exact biological mechanisms underlying these effects should be addressed in future studies. |
| Databáze: | OpenAIRE |
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