Extracellular Histones H3 as a Prognostic Blood Marker for Delayed Liver Function Recovery After Donor Hepatectomy
| Autor: | Veysel Ersan, Barış Otlu, Eldar Aliyev, Burak Isik, Sezai Yilmaz, Volkan Ince, Yunus Karipkiz, Nuru Bayramov, Namig Novruzov |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Gastroenterology Histones Histone H3 Postoperative Complications Internal medicine medicine Hepatectomy Humans Prospective Studies Prospective cohort study Liver injury Transplantation Univariate analysis Receiver operating characteristic business.industry Liver Neoplasms Recovery of Function Prognosis medicine.disease ROC Curve Biomarker (medicine) Surgery Liver function business |
| Zdroj: | Transplantation Proceedings. 53:2305-2311 |
| ISSN: | 0041-1345 |
| Popis: | Background Early prediction of liver dysfunction after liver resection remains a challenge. We hypothesized that extracellular histone concentrations are a promising new biomarker for the detection of liver injury after donor hepatectomy. Methods This prospective study considered 93 living donors who underwent hepatectomy. Blood samples of donors were collected on postoperative day 1, and histone levels in the plasma samples of the patients were measured with total histone H3 sandwich ELISA kits. Among 86 right lobe donors, 23 (26.7%) were deemed to have a delayed liver function recovery according to the International Study Group of Liver Surgery's definition of posthepatectomy liver failure, whereas 63 (73.3%) were considered to have an adequate liver function recovery. Results The area under the receiver operating characteristic (ROC) curve for circulating histones in predicting persistent liver dysfunction was 0.618 ± 0.06 (95% confidence interval [CI], 0.501-0.735; P = .091). The cutoff point value obtained from the analysis of ROC curves was 0.895, with a sensitivity of 95.7% and a specificity of 32.9%, respectively, for examining a delayed liver function recovery (P = .015). The Fisher analysis significantly verified these results empirical influence function % 7.90 (95% CI, 3.91-11.90; P = .006). The univariate analysis determined that postoperative histones were identified as an independent risk factor of delayed liver function recovery (odds ratio, 10.8; 95% CI, 1.4-84.9; P = .024). Conclusions The circulating histone negatively correlates with liver dysfunctions after donor hepatectomy and had the best value in predicting liver dysfunction within 24 hours after liver resection. |
| Databáze: | OpenAIRE |
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