Emerging therapeutic targets in chronic heart failure: part I
| Autor: | Volker Roenicke, Stéphane Leclair, Anke Hoffmann, Michael Becker, Tania Szado, Thomas Kirsch, Oliver Stoss, Barbara T Navé, Thomas Henkel |
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| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
Heart Failure MAP Kinase Signaling System Clinical Biochemistry Fatty Acids Muscle Proteins Arrhythmias Cardiac Cardiovascular Agents Cardiomyopathy Hypertrophic Calcium Channel Blockers Ion Channels Rats Mice Drug Discovery Molecular Medicine Animals Humans PPAR alpha Calcium Channels Calcium Signaling Energy Metabolism Anti-Arrhythmia Agents Antihypertensive Agents Transcription Factors |
| Zdroj: | Expert opinion on therapeutic targets. 6(6) |
| ISSN: | 1744-7631 |
| Popis: | Chronic heart failure (CHF) is a life threatening disease with an enormous medical requirement. Approximately 15 million people worldwide suffer from CHF. The prevalence will inevitably increase due to the ageing population. Nevertheless, current treatment options based on angiotensin-converting enzyme inhibitors and beta-adrenergic receptor antagonists merely slow progression of the disease. Novel treatment concepts based on new therapeutic targets must have the capability to reverse the severity of this disease. This review, focusing on the emerging targets in the most promising therapeutic areas for the treatment of CHF, will be divided into two parts. In Part I, disease concepts such as altered calcium handling and ion channel activity, pathophysiological hypertrophy and inefficient cardiac metabolism are discussed. Validation status and potential therapeutic value for new targets in each research field is given by summarising the results of in vitro and in vivo studies. |
| Databáze: | OpenAIRE |
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