The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry
| Autor: | Hiroki Fujii, Udai Nakamura, Masahito Yoshinari, Toshiaki Ohkuma, Takanari Kitazono, Masanori Iwase, Tamaki Jodai-Kitamura, Yuji Komorita, Akiko Sumi, Hitoshi Ide |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Sarcopenia Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology 03 medical and health sciences chemistry.chemical_compound Fractures Bone 0302 clinical medicine Endocrinology Risk Factors Diabetes mellitus Internal medicine Internal Medicine Medicine Humans 030212 general & internal medicine Prospective Studies Registries Cystatin C Aged Creatinine biology business.industry Surrogate endpoint Hazard ratio General Medicine Bone fracture medicine.disease chemistry Diabetes Mellitus Type 2 biology.protein Female business |
| Zdroj: | Diabetes research and clinical practice. 146 |
| ISSN: | 1872-8227 |
| Popis: | Aims Sarcopenia is involved in the pathogenesis of increased fracture risk associated with diabetes. The serum creatinine to cystatin C (Cr/CysC) ratio has been reported as a surrogate marker for muscle mass. We aimed to prospectively investigate the relationship between the Cr/CysC ratio and fracture risk. Methods We followed 1911 postmenopausal women and 2689 men with type 2 diabetes (mean age, 66 years) for a median of 5.3 years, and divided into Cr/CysC ratio quartiles by sex. The primary outcome was fragility fractures and the secondary outcome was any fracture. Results Fragility fractures occurred in 192 participants, and any fracture occurred in 645 participants. Multivariate-adjusted hazard ratios (95% CI) for fragility fractures were 2.15 (1.19–3.88) (Q1), 1.63 (0.89–2.98) (Q2), 1.34 (0.72–2.51) (Q3) and 1.0 (ref.) (Q4) in postmenopausal women, and 1.75 (0.64–4.50) (Q1), 2.09 (0.83–5.26) (Q2), 1.56 (0.58–4.18) (Q3) and 1.0 (ref.) (Q4) in men. Those for any fracture were 1.46 (1.07–1.98) (Q1), 1.33 (0.98–1.81) (Q2), 1.40 (1.03–1.88) (Q3) and 1.0 (ref.) (Q4) in postmenopausal women, and 2.33 (1.54–3.54) (Q1), 2.02 (1.54–3.04) (Q2), 1.13 (0.71–1.78) (Q3) and 1.0 (ref.) (Q4) in men. Conclusions A lower Cr/CysC ratio is a significant risk factor for fractures in patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
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