INFRAFRONTIER quality principles in systemic phenotyping
| Autor: | Hilke Ehlich, Reetta Vuolteenaho, Michael Raess, Vasileios Ntafis, Ana Zarubica, Bernard Malissen, Dimitris L. Kontoyiannis, Mohammed Selloum, Tania Sorg, Ann M Flenniken, Martin Hrabě de Angelis, Claudia Stoeger, Yann Herault, Isabelle Goncalves Da Cruz, George Kollias, Sarka Suchanova, Heather Cater, Reetta Hinttala, Radislav Sedlacek, Sara Wells, Colin McKerlie, Anne-Marie Mura, Steve D.M. Brown, Jan Rozman |
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| Přispěvatelé: | MRC Harwell Institute [UK], Lunenfeld-Tanenbaum Research Institute [Toronto, Canada], Institut Clinique de la Souris (ICS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Immunophénomique (CIPHE), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Alexander Fleming Biomedical Sciences Research Center, Partenaires INRAE, Helmholtz-Zentrum München (HZM), Institute of Molecular Genetics of the Czech Academy of Sciences (IMG / CAS), Czech Academy of Sciences [Prague] (CAS), University of Oulu, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), Technische Universität München [München] (TUM), The Hospital for sick children [Toronto] (SickKids), University of Toronto, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), INFRAFRONTIER GmbH [Neuherberg], Biomedical Sciences Research Centre Alexander Fleming [Vari, Greece] (BSRC), Helmholtz Zentrum München = German Research Center for Environmental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Service (systems architecture)
media_common.quotation_subject [SDV]Life Sciences [q-bio] Interoperability Context (language use) Biology 03 medical and health sciences Preclinical research Mice 0302 clinical medicine Genetics Animals Quality (business) 030304 developmental biology media_common Mammals 0303 health sciences [SDV.GEN]Life Sciences [q-bio]/Genetics Genome European research [SDV.BA]Life Sciences [q-bio]/Animal biology Reproducibility of Results Internal quality Disease Models Animal Risk analysis (engineering) Key (cryptography) 030217 neurology & neurosurgery |
| Zdroj: | Mammalian Genome Mammalian Genome, Springer Verlag, 2021, ⟨10.1007/s00335-021-09892-2⟩ Mammalian Genome, 2022, 33 (1), pp.120-122. ⟨10.1007/s00335-021-09892-2⟩ Mamm. Genome, DOI: 10.1007/s00335-021-09892-2 (2021) |
| ISSN: | 0938-8990 1432-1777 |
| Popis: | Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by developing internal quality principles for its different service areas, that provides a quality framework for its operational activities. This article introduces the INFRAFRONTIER Quality Principles in Systemic Phenotyping of genetically altered mouse models. A total of 11 key principles are included, ranging from general requirements for compliance with guidelines on animal testing, to the need for well-trained personnel and more specific standards such as the exchange of reference lines. Recently established requirements such as the provision of FAIR (Findable, Accessible, Interoperable, Reusable) data are also addressed. For each quality principle, we have outlined the specific context, requirements, further recommendations, and key references. |
| Databáze: | OpenAIRE |
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