Vascular uptake on 18F-sodium fluoride positron emission tomography: precursor of vascular calcification?
| Autor: | Jonas W. Bartstra, Sabine R. Zwakenberg, Joline W.J. Beulens, Jelmer M. Wolterink, Pim A. de Jong, Annemarie M. den Harder, Riemer H. J. A. Slart, Willem P.Th.M. Mali, Wilko Spiering, Gert Luurtsema |
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| Přispěvatelé: | Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR), Molecular Neuroscience and Ageing Research (MOLAR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Biomedical Engineering and Physics, ACS - Atherosclerosis & ischemic syndromes, Epidemiology and Data Science, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, Radiology and nuclear medicine, ACS - Diabetes & metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
positron emission tomography
medicine.diagnostic_test business.industry computed tomography Computed tomography 030204 cardiovascular system & hematology medicine.disease Calcification 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Positron emission tomography Sodium fluoride Medicine Radiology Nuclear Medicine and imaging atherosclerosis Cardiology and Cardiovascular Medicine business Nuclear medicine Vascular calcification medial artery calcification |
| Zdroj: | Journal of Nuclear Cardiology, 28, 2244-2254. SPRINGER den Harder, A M, Wolterink, J M, Bartstra, J W, Spiering, W, Zwakenberg, S R, Beulens, J W, Slart, R H J A, Luurtsema, G, Mali, W P & de Jong, P A 2020, ' Vascular uptake on 18 F-sodium fluoride positron emission tomography : precursor of vascular calcification? ', Journal of Nuclear Cardiology, vol. 2020, s12350-020-02031-5 . https://doi.org/10.1007/s12350-020-02031-5 Journal of nuclear cardiology. Springer New York Journal of Nuclear Cardiology, 2020:s12350-020-02031-5 |
| ISSN: | 1071-3581 |
| DOI: | 10.1007/s12350-020-02031-5 |
| Popis: | Background Microcalcifications cannot be identified with the present resolution of CT; however, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification. The primary objective of this study was to assess whether 18F-NaF activity can assess the presence and predict the progression of CT detectable vascular calcification. Methods and Results The data of two longitudinal studies in which patients received a 18F-NaF PET-CT at baseline and after 6 months or 1-year follow-up were used. The target to background ratio (TBR) was measured on PET at baseline and CT calcification was quantified in the femoral arteries at baseline and follow-up. 128 patients were included. A higher TBR at baseline was associated with higher calcification mass at baseline and calcification progression (β = 1.006 [1.005-1.007] and β = 1.002 [1.002-1.003] in the studies with 6 months and 1-year follow-up, respectively). In areas without calcification at baseline and where calcification developed at follow-up, the TBR was .11–.13 (P Conclusion The activity of 18F-NaF is related to the amount of calcification and calcification progression. In areas where calcification formation occurred, the TBR was slightly but significantly higher. |
| Databáze: | OpenAIRE |
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