Sea Lions Develop Human-like Vernix Caseosa Delivering Branched Fats and Squalene to the GI Tract
| Autor: | Lauren Palmer, Dong Hao Wang, Richard F. Collins, Erika Nilson, J. Thomas Brenna, Rinat R. Ran-Ressler, Judy St. Leger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Squalene Amniotic fluid Zalophus californianus Science Human skin Biology Article Microbiology 03 medical and health sciences chemistry.chemical_compound Fetus Species Specificity Pregnancy Animals Humans Vernix Caseosa Sea lion Vernix caseosa Multidisciplinary Fatty Acids Infant Newborn biology.organism_classification Sea Lions Gastrointestinal Tract 030104 developmental biology chemistry Human fetal Medicine Female |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Vernix caseosa, the white waxy coating found on newborn human skin, is thought to be a uniquely human substance. Its signature characteristic is exceptional richness in saturated branched chain fatty acids (BCFA) and squalene. Vernix particles sloughed from the skin suspended in amniotic fluid are swallowed by the human fetus, depositing BCFA/squalene throughout the gastrointestinal (GI) tract, thereby establishing a unique microbial niche that influences development of nascent microbiota. Here we show that late-term California sea lion (Zalophus californianus) fetuses have true vernix caseosa, delivering BCFA and squalene to the fetal GI tract thereby recapitulating the human fetal gut microbial niche. These are the first data demonstrating the production of true vernix caseosa in a species other than Homo sapiens. Its presence in a marine mammal supports the hypothesis of an aquatic habituation period in the evolution of modern humans. |
| Databáze: | OpenAIRE |
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