Congenital Malformations, Chromosomal Abnormalities and Perinatal Results in IVF/ICSI Newborns Resulting from Very Poor Quality Embryos: A Case-Control Study
| Autor: | Z. Larreategui, R. Mendoza, F. Ayerdi, J.I. Pijoan, Roberto Matorras, Antonia Expósito, J. Burgos, S. Perez, M.J. de los Santos, L. Martínez Indart |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Fertilization in Vitro Poor quality Intracytoplasmic sperm injection Congenital Abnormalities Pregnancy medicine Humans Sperm Injections Intracytoplasmic Chromosome Aberrations In vitro fertilisation Obstetrics business.industry Case-control study Obstetrics and Gynecology Embryo Congenital malformations Ivf icsi Embryo Transfer medicine.disease Obstetric Labor Complications Reproductive Medicine Spain Case-Control Studies Female business |
| Zdroj: | Gynecologic and Obstetric Investigation. 79:83-89 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000353605 |
| Popis: | Aims: To explore whether the transfer of very poor quality (VPQ) embryos is associated with an increase in congenital malformations or perinatal problems. Methods: In this retrospective case-control study, 74 children conceived by in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) resulting exclusively from the transfer of VPQ embryos were compared with 1,507 children born after the transfer of top morphological quality (TQ) embryos over the same period of time in the same centers. Results: The prevalence of birth defects in children resulting from VPQ embryos was 1.35% (1/74), similar to the 1.72% (26/1,507) when only TQ embryos were transferred; the rate of chromosomal abnormalities detected was also similar (0.0 vs. 0.4%), as was perinatal mortality. After correcting for multiplicity (higher in the TQ group), the aforementioned parameters remained similar in the two groups. Conclusion: Congenital malformations and perinatal complications do not seem to be more common in children born after transfer of VPQ embryos in IVF/ICSI cycles. Given our preliminary data, which need to be confirmed in much larger studies, when only VPQ embryos are available for transfer in IVF/ICSI cycles, we do not believe that they should be discarded with the intention of avoiding birth defects or perinatal complications. |
| Databáze: | OpenAIRE |
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