Electrical stimulation sensorimotor mapping with stereo-EEG
| Autor: | Jonathan Dudley, James L. Leach, Timothy Holloway, Paul S. Horn, Craig Scholle, Brian Ervin, Ravindra Arya, Leonid Rozhkov, Jason Buroker, Hansel M. Greiner, Francesco T. Mangano, Anna W. Byars, Katherine D. Holland |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Drug Resistant Epilepsy medicine.medical_specialty Adolescent media_common.quotation_subject Stimulation Audiology Sensitivity and Specificity 050105 experimental psychology Young Adult 03 medical and health sciences Epilepsy 0302 clinical medicine Neuroimaging Stereo eeg Physiology (medical) Perception medicine Humans 0501 psychology and cognitive sciences Epilepsy surgery Child media_common Brain Mapping business.industry 05 social sciences Motor control Electroencephalography medicine.disease Magnetic Resonance Imaging Electric Stimulation Sensory Systems Neurology Child Preschool Diagnostic odds ratio Female Sensorimotor Cortex Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurophysiology. 131:1691-1701 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2020.04.159 |
| Popis: | We evaluated stereo-EEG electrical stimulation mapping (ESM) for localization of anatomic sensorimotor parcels in pediatric patients with drug-resistant epilepsy. We also analyzed sensorimotor and after-discharge thresholds, and the somatotopy of sensorimotor responses.ESM was performed with 50 Hz, biphasic, 2-3 s trains, using 1-9 mA current. Pre- and post-implant neuroimaging was co-registered and intersected with Neurosynth reference, to classify each electrode contact as lying within/outside an anatomic sensorimotor parcel. Indices of diagnostic performance were computed. Sensorimotor and after-discharge thresholds were analyzed using multivariable linear mixed models.In 15 patients (6 females), aged 5.5-21.2 years, ESM showed high accuracy (0.80), high specificity (0.86), and diagnostic odds ratio (11.4, p 0.0001) for localization of sensorimotor parcels. Mean sensorimotor threshold (3.4 mA) was below mean after-discharge threshold (4.2 mA, p = 0.0004). Sensorimotor and after-discharge thresholds showed a significant decrease with increasing intelligence quotient. Somatotopy of sensorimotor responses was mapped to standardized brain parcels.We provide evidence for diagnostic validity and safety of stereo-EEG sensorimotor ESM.The somatotopy of sensorimotor responses elicited with electrical stimulation provide new insights into mechanisms of motor control and sensory perception. |
| Databáze: | OpenAIRE |
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