Effects of Hadacidin on Human Tumors Grown in Eggs and Rats

Autor:	John J. Harris, George W. Woolley, E. Yap-Guevara, Morris N. Teller
Rok vydání:	1962
Předmět:	Glycine Antineoplastic Agents Neoplasms Experimental Pharmacology Biology Chick embryos General Biochemistry Genetics and Molecular Biology Rats chemistry.chemical_compound Hadacidin chemistry Neoplasms Immunology medicine Animals Cortisone medicine.drug
Zdroj:	Experimental Biology and Medicine. 110:1-4
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-110-27402
Popis:	SummaryFour transplantable human tumors (H. Ep. 3, H.S. 1, . Ad. 1 and A-42) were gorwn on the CAM of chick embryos and used to determine the anti-tumor potential of hadacidin. In testing samples of hadacidin, there was consistent anti-tumor activity. When a comparison among the tumor types of their response to hadacidin was made, A-42 appeared to be consistently more sensitive to hadacidin than were the other types of tumors. Using two different routes of administration, intraperitoneal and per os, hadacidin inhibited the growth of H.S. 1 in the x-irradiated and cortisone treated rat. The positive results obtained in the mammalian host are further indications of the antitumor potentials of hadacidin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9b44c2edb9ddfffa164fb7097d4e09 https://doi.org/10.3181/00379727-110-27402 Zobrazit plný text záznamu