Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits

Autor: Dagmara Klopotowska, Joanna Kolniak-Ostek, Krzysztof P. Rutkowski, Dorota Kruczyńska, Anna Skorupińska
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Antioxidant
030309 nutrition & dietetics
DPPH
medicine.medical_treatment
Pharmaceutical Science
Antioxidants
Analytical Chemistry
Pyrus
chemistry.chemical_compound
suitability for processing
Triterpene
Neoplasms
Drug Discovery
Food science
health-promoting properties
Carotenoid
chemistry.chemical_classification
0303 health sciences
PEAR
biology
Cytotoxins
food and beverages
04 agricultural and veterinary sciences
040401 food science
Neoplasm Proteins
Chemistry (miscellaneous)
MCF-7 Cells
Molecular Medicine
HT29 Cells
Pyrus communis
UPLC-MS
Article
lcsh:QD241-441
03 medical and health sciences
0404 agricultural biotechnology
lcsh:Organic chemistry
Ursolic acid
medicine
Humans
Physical and Theoretical Chemistry
bioactive compounds
Organic Chemistry
Polyphenols
pear
biology.organism_classification
Antineoplastic Agents
Phytogenic
chemistry
Polyphenol
A549 Cells
Cyclooxygenase 2
Fruit
Cyclooxygenase 1
Zdroj: Molecules
Volume 25
Issue 19
Molecules, Vol 25, Iss 4444, p 4444 (2020)
ISSN: 1420-3049
DOI: 10.3390/molecules25194444
Popis: Consuming food that is rich in antioxidants reduces the risk of developing chronic diseases and oxidative stress. Fruits and vegetables are an excellent source of substances with antioxidant and pro-health properties. Such raw materials, characterized by a high content of polyphenolic compounds and antioxidant capacity, include pear fruits. In this study, the concentrations of bioactive compounds, as well as the antioxidant, anti-inflammatory, and antiproliferative activity in fruits of five selected pear cultivars were determined and compared. LC&ndash
MS and UPLC&ndash
PDA methods were used to determine the polyphenolic, carotenoid, chlorophyll, and triterpenoid profiles and content, and the antioxidant activity was analyzed using DPPH and ferric-reducing ability of plasma (FRAP) tests. The anti-inflammatory activity was determined against COX-1 and COX-2 enzymes. The cytotoxic activity of the test compounds was assessed against six tumor cell lines. The results showed that the major group of phenolic compounds in all cultivars was phenolic acids. In the group of chromoplastic pigments, chlorophyllide a and 9-cis-&beta
carotene were the major compounds, while in the triterpene group, ursolic acid was dominant. The antioxidant potential correlated with the content of polyphenols and carotenoids, and was the strongest for the &lsquo
Radana&rsquo
cultivar. The highest antiproliferative activity in all varieties was established for bladder cancer.
Databáze: OpenAIRE
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