Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes: A Prespecified Analysis of the Benedict Trial
| Autor: | Piero Ruggenenti, Ilian Iliev, Roberto Trevisan, Antonio Bossi, Maria Ganeva, Paolo Cravedi, Bogdan Ene-Iordache, Annalisa Perna, Stefano Tadini, Marco Filipponi, Giuseppe Remuzzi |
|---|---|
| Přispěvatelé: | Ruggenenti, P, Iliev, I, Filipponi, M, Tadini, S, Perna, A, Ganeva, M, Ene-Iordache, B, Cravedi, P, Trevisan, R, Bossi, A, Remuzzi, G |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Trandolapril
medicine.medical_specialty Article Subject Type 2 diabetes lcsh:Ophthalmology Interquartile range Internal medicine ACE inhibitor medicine cardiovascular diseases type 2 diabete biology business.industry Incidence (epidemiology) Angiotensin-converting enzyme Diabetic retinopathy medicine.disease Ophthalmology diabetic retinopathy lcsh:RE1-994 Concomitant biology.protein Clinical Study business medicine.drug Retinopathy |
| Zdroj: | Journal of Ophthalmology Journal of Ophthalmology, Vol 2010 (2010) |
| ISSN: | 2090-0058 2090-004X |
| Popis: | Background. The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined.Methods. We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or non-ACEi therapy who had preproliferative or proliferative retinopathy at baseline.Results. Over a median (interquartile range) follow-up period of 35.8 (12.4–60.7) months, retinopathy regressed in 27 patients (30.0%). Regression occurred in 18 of 42 patients (42.9%) on ACEi and in 9 of 48 (18.8%) on non-ACEi therapy (adjusted for predefined baseline covariates HR (95% CI): 2.75 (1.18–6.42),P=.0193). Concomitant treatment with or without Non-Dihydropyridine Calcium Channel Blockers (ndCCBs) did not appreciably affect the incidence of retinopathy regression.Conclusions. Unlike ndCCB, ACEi therapy may have an additional effect to that of intensified BP and metabolic control in promoting regression of diabetic retinopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|