Quantitative and qualitative analysis of regulatory T cells in B cell chronic lymphocytic leukemia
| Autor: | Vasiliki Pappa, George Dimitriadis, Elias Kyriakou, Stella Kokkori, Christos K. Kontos, Heleni-Dikaia Ioannidou, Frieda Kontsioti, Eugene Konsta, Athanassios D. Velentzas, Aris Spathis, S. Papageorgiou, Diamantina Vasilatou, Irene Glezou, Konstantinos Gkontopoulos, Petros Karakitsos, Georgia Stavroulaki, Myrofora Vikentiou, Vassiliki E. Mpakou, Efthimia Mpazani |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Chronic lymphocytic leukemia Clone (cell biology) chemical and pharmacologic phenomena Apoptosis Biology T-Lymphocytes Regulatory Immunophenotyping Pathogenesis 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases medicine Humans IL-2 receptor Interleukin-7 receptor neoplasms Aged Cell Proliferation Aged 80 and over hemic and immune systems Hematology Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell CD4 Lymphocyte Count 030104 developmental biology Oncology Immunoediting Immunology Female 030215 immunology |
| Zdroj: | Leukemia research. 60 |
| ISSN: | 1873-5835 |
| Popis: | Accumulated data indicate a significant role of T cell dysfunction in the pathogenesis of chronic lymphocytic leukemia. In CLL, regulatory T cells are significantly higher and show lower apoptotic levels compared to healthy donors. We demonstrate that CLL derived CD4 + CD25 − CD127 − and CD4 + CD25 low CD127 − subpopulations share a common immunophenotypic profile with conventional Tregs and are associated with advanced stage disease. We further provide evidence that the increased number of Tregs contributes indirectly to the proliferation of the CLL clone, by suppressing the proliferation of Teffs which in turn suppress CLL cells. These data are further supported by our observations that CLL derived Tregs appear rather incapable of inducing apoptosis of both normal B cells and CLL cells, in contrast to normal Tregs, suggesting an immunoediting effect of CLL cells on Tregs which negatively affects the functionality of the latter and contributes to the failure of Tregs in CLL to efficiently eliminate the abnormal clone. |
| Databáze: | OpenAIRE |
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