Brain amygdala volume increases in veterans and active-duty military personnel with combat-related Post-traumatic Stress Disorder and mild Traumatic Brain Injury
| Autor: | Ashley Robb Swan, Dewleen G. Baker, Joel Pieper, Mithun Diwakar, James Swan, Sharon Nichols, Mingxiong Huang, Charles Huang, Roland R. Lee, Sarah Z Mahasin, Douglas G. Chang, Annemarie Angeles Quinto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 030506 rehabilitation Traumatic brain injury Left amygdala Physical Therapy Sports Therapy and Rehabilitation Amygdala Article Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Medicine Humans Brain Concussion Veterans Combat Disorders business.industry Rehabilitation Organ Size medicine.disease Posttraumatic stress medicine.anatomical_structure Military Personnel Anesthesia Case-Control Studies Cohort Automatic segmentation Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery Active duty military Healthcare system |
| Zdroj: | J Head Trauma Rehabil |
| Popis: | Objective To identify amygdalar volumetric differences associated with posttraumatic stress disorder (PTSD) in individuals with comorbid mild traumatic brain injury (mTBI) compared with those with mTBI-only and to examine the effects of intracranial volume (ICV) on amygdala volumetric measures. Setting Marine Corps Base and VA Healthcare System. Participants A cohort of veterans and active-duty military personnel with combat-related mTBI (N = 89). Design Twenty-nine participants were identified with comorbid PTSD and mTBI. The remaining 60 formed the mTBI-only control group. Structural images of brains were obtained with a 1.5-T MRI scanner using a T1-weighted 3D-IR-FSPGR pulse sequence. Automatic segmentation was performed in Freesurfer. Main measures Amygdala volumes with/without normalizations to ICV. Results The comorbid mTBI/PTSD group had significantly larger amygdala volumes, when normalized to ICV, compared with the mTBI-only group. The right and left amygdala volumes after normalization to ICV were 0.122% ± 0.012% and 0.118% ± 0.011%, respectively, in the comorbid group compared with 0.115% ± 0.012% and 0.112% ± 0.009%, respectively, in the mTBI-only group (corrected P Conclusions The ICV normalization analysis performed here may resolve previous literature discrepancies. This is an intriguing structural finding, given the role of the amygdala in the challenging neuroemotive symptoms witnessed in casualties of combat-related mTBI and PTSD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|