Differentiation and programmed cell death in SA-45 tumour treated with bone inducer
| Autor: | T. Arshavskaya, H. I. Roach, J. Erenpreisa |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Programmed cell death
Time Factors Stromal cell Demineralized bone matrix Fibrosarcoma Cellular differentiation Bone Matrix Apoptosis Cell Differentiation Cell Biology General Medicine Biology Immunohistochemistry Molecular biology Rats Microscopy Electron Parenchyma Immunology Ultrastructure Animals Inducer Collagen Cell Division |
| Zdroj: | Cell Biology International. 18:927-936 |
| ISSN: | 1065-6995 |
| Popis: | The relationship between differentiation and concerted cell death was studied using ultrastructural, histochemical and immunochemical methods in solid rat fibrosarcoma Sa-45 grown in the presence of demineralized bone matrix. The control tumour consisted mostly of undifferentiated cells with few poorly or moderately differentiated cells. In the presence of the inducer, cells with a more differentiated pattern appeared in the surrounding area. The proliferative activity in the presence of the inducer was 3 to 5 times lower but the apoptotic index was higher than in the controls. However, complete differentiation was induced only in stromal cells, whereas the parenchymal cells showed signs of enhanced but incomplete differentiation. The ultrastructural signs of programmed cell death progressed in them faster than the corresponding features of maturation, thus leaving differentiation incomplete. |
| Databáze: | OpenAIRE |
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