Cost Effectiveness of Darunavir/Ritonavir 600/100mg bid in Treatment-Experienced, Lopinavir-Naive, Protease Inhibitor-Resistant, HIV-Infected Adults in Belgium, Italy, Sweden and the UK

Autor: Jonas Hjelmgren, Gabriele Allegri, K Moeremans, Lindsay Hemmett, Erik Smets
Rok vydání: 2010
Předmět:
Male
Oncology
Enfuvirtide
Cost effectiveness
Cost-Benefit Analysis
HIV Infections
Lopinavir
Antiretrovirals
therapeutic use
Cost-utility
Darunavir
therapeutic use
HIV-infections
treatment
Lopinavir
therapeutic use
Ritonavir
therapeutic use
jel:I1
Belgium
immune system diseases
Antiretroviral Therapy
Highly Active
Multicenter Studies as Topic
Sida
Darunavir
Randomized Controlled Trials as Topic
Sulfonamides
jel:Z
biology
Health Policy
virus diseases
Health Care Costs
Viral Load
jel:I11
Markov Chains
Italy
jel:I18
jel:I19
RNA
Viral
Female
Quality-Adjusted Life Years
medicine.drug
Adult
medicine.medical_specialty
jel:D
Pyrimidinones
jel:C
jel:I
Clinical Trials
Phase II as Topic
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
Drug Resistance
Viral
medicine
Humans
Protease inhibitor (pharmacology)
Sweden
Pharmacology
Ritonavir
business.industry
Public Health
Environmental and Occupational Health
HIV Protease Inhibitors
medicine.disease
biology.organism_classification
United Kingdom
CD4 Lymphocyte Count
Immunology
HIV-1
business
Zdroj: PharmacoEconomics. 28:147-167
ISSN: 1179-2027
1170-7690
DOI: 10.2165/11587500-000000000-00000
Popis: Background: Using data from the phase IIb POWER trials, darunavir boosted with low-dose ritonavir (DRV/r; 600/100 mg twice daily; bid)-based highly active antiretroviral therapy (HAART) was shown to be significantly more efficacious and cost effective than other protease inhibitor (PI)-based therapy in highly treatment-experienced, HIV-1-infected adults. Furthermore, in the phase III TITAN trial (TMC114-C214), DRV/r 600/100 mg bid-based HAART generated a superior 48-week virological response rate compared with standard-of-care lopinavir/ritonavir (LPV/r; 400/100 mg bid)-based therapy in treatment-experienced, lopinavir-naive patients, and in particular those with one or more International AIDS Society - USA (IAS-USA) primary PI resistance-associated mutations at baseline. These patients had a broader degree of previous PI use/failure (0-≥2) than the POWER patients. Objectives: To determine whether DRV/r 600/100 mg bid-based HAART is cost effective compared with LPV/r-based therapy, from the perspective of Belgian, Italian, Swedish and UK reimbursement authorities, when used in treatment-experienced patients similar to TITAN patients with one or more IAS-USA primary PI mutations at baseline. Methods: An existing Markov model containing health states defined by CD4 cell count ranges (>500, 351-500, 201-350, 101-200, 51-100 and 0-50 cells/mm) and an absorbing state of death was adapted for use in the above-mentioned healthcare settings. Baseline demographics, CD4 cell count distribution, antiretroviral drug usage, virological/immunological response rates and matching transition probabilities were based on data collected during the first 48 weeks of therapy in the modelled subgroup of TITAN patients and the published literature. After treatment failure, patients were assumed to switch to a follow-on combination regimen. For each health state, utility values and mortality rates were obtained from the published literature. Data from local observational studies (Belgium, Sweden and Italy) or the published literature (UK) were used to determine resource-use patterns and costs associated with each CD4 cell count range. Unit costs were derived from official local sources; a lifetime horizon was taken and discount rates were chosen based on local guidelines. Results: The base-case analysis predicted quality-adjusted life year (QALY) gains of 0.785 in Belgium, 0.608 in Italy, 0.584 in Sweden and 0.550 in the UK when DRV/r-based therapy was used instead of LPV/r-based treatment. The estimated base-case incremental cost-effectiveness ratios (ICERs) were &U20AC;6964/QALY gained in Belgium, &U20AC;9277/QALY gained in Italy, &U20AC;6868 (SEK69 687)/QALY gained in Sweden and &U20AC;14 778 (£12 612)/QALY gained in the UK. Assuming a threshold of &U20AC;30 000/QALY gained, DRV/r-based therapy remained cost effective over most parameter ranges tested in extensive one-way sensitivity analyses. The variation of immunological response rates and the time horizon were identified as important drivers of cost effectiveness. Probabilistic sensitivity analysis revealed a greater than 70% probability of achieving an ICER below this threshold in all four healthcare settings. Conclusion: From the perspective of Belgian, Italian, Swedish and UK payers, DRV/r 600/100 mg bid-based HAART is predicted to be cost effective compared with LPV/r 400/100 mg bid-based therapy, when used to manage treatment experienced, lopinavir-naive, PI-resistant, HIV-infected adults with a broad range of previous PI use/failure.
Databáze: OpenAIRE
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