Starvation and Seizures
| Autor: | Mary P. Leckie, Kenneth L. Malas, Darryl C. DeVivo |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors Sodium Hydroxybutyrates chemistry.chemical_element Ketone Bodies Carbohydrate metabolism Hypoglycemia Arts and Humanities (miscellaneous) Seizures Internal medicine medicine Animals Glycolysis Energy charge Adenosine Triphosphatases Chemistry Brain Water-Electrolyte Balance Pyruvate dehydrogenase complex medicine.disease Rats Endocrinology Starvation Ketone bodies Carbohydrate Metabolism Neurology (clinical) Oxidation-Reduction Phosphofructokinase |
| Zdroj: | Archives of Neurology. 32:755 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.1975.00490530077008 |
| Popis: | Acute starvation of adult rats resulted in a rise in the electroconvulsive threshold at 48 hours (P less than .10) and at 72 hours (P less than .01), but not at 24 hours. Biochemical correlates included (1) ketonemia and mild hypoglycemia in the blood; (2) a significant rise in the brain cytoplasmic phosphorylation potential and in the energy charge potential; (3) a shift in the brain cytoplasmic oxidation-reduction potential to a more oxidized state; (4) probable partial inhibitions in brain phosphofructokinase and pyruvate dehydrogenase; and (5) relatively small increases in brain sodium (4.1%), potassium (2.4%), and chloride (4.3%). No major differences were seen in brain water content or adenosine triphosphatase activity. The observed cerebral biochemical alterations are believed to be the consequence of increased ketone body utilization, although the precise relationship to the alteration in the electroconvulsive threshold remains unclear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|