Induced Dipoles and Possible Modulation of Wireless Effects in Implanted Electrodes. Effects of Implanting Insulated Electrodes on an Animal Test to Screen Antidepressant Activity
| Autor: | Laura Perez-Caballero, Eulalia Pujades, Juan Nacher, Vicent Teruel-Martí, Nieves Casañ-Pastor, Esther Berrocoso, Hector Carceller |
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| Přispěvatelé: | European Commission, Ministerio de Economía y Competitividad (España), Junta de Andalucía, Centro de Investigación Biomédica en Red Salud Mental (España), Psicología |
| Rok vydání: | 2021 |
| Předmět: |
Deep Brain Stimulation
depression infralimbic cortex rat induced dipoles implanted materials feedback interactions insulating conducting materials Deep brain stimulation medicine.medical_treatment Infralimbic cortex Stimulation Induced dipoles Article Conducting materials medicine Implanted materials Insulating Feedback interactions business.industry Depression General Medicine medicine.disease Astrogliosis medicine.anatomical_structure Gliosis Modulation Electrode Medicine Rat Neuron medicine.symptom business Biomedical engineering |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Journal of Clinical Medicine; Volume 10; Issue 17; Pages: 4003 Journal of Clinical Medicine, Vol 10, Iss 4003, p 4003 (2021) J. Clin. Med. 2021, 10(17), 4003 Journal of Clinical Medicine RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz |
| Popis: | There is evidence that Deep Brain Stimulation (DBS) produces health benefits in patients even before initiating stimulation. Furthermore, DBS electrode insertion in rat infralimbic cortex (ILC) provokes antidepressant-like effects before stimulation, due to local inflammation and astrogliosis. Consequently, a significant effect of implanting electrodes is suspected. External fields, similar in magnitude to the brain’s endogenous fields, induce electric dipoles in conducting materials, in turn influencing neural cell growth through wireless effects. To elucidate if such dipoles influence depressive-like behavior, without external stimulation, the comparative effect of conducting and insulated electrodes along with the glial response is studied in unstressed rats. Naïve and implanted rats with electrically insulated or uninsulated steel electrodes were evaluated in the modified forced swimming test and expression of ILC-glial markers was assessed. An antidepressant-like effect was observed with conducting but not with insulated electrodes. Gliosis was detected in both groups, but astroglial reactivity was larger near uninsulated electrodes. Thus, induced dipoles and antidepressant-like effects were only observed with conducting implants. Such correlation suggests that dipoles induced in electrodes by endogenous fields in turn induce neuron stimulation in a feedback loop between electrodes and neural system. Further research of the effects of unwired conducting implants could open new approaches to regulating neuronal function, and possibly treat neurological disorders. This study was also supported by grants co-financed by the “Fondo Europeo de Desarrollo Regional” (FEDER)-UE “A way to build Europe” from the “Ministerio de Economía y Competitividad” (MINECO: RTI2018-099778-B-I00 (to E.B.), RTI2018-098269-B-I00 (to J.N.) and RTI2018-097753- B-I00 (to N.C.P.) and “Juan de la Cierva Formación” postdoctoral grant FJC2018-037958-I (to L.P.C.)) and PID2019-108562GB-I00 (to V.T.M); the “Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía” (CTS-510, to E.B.); the Severo Ochoa Program CEX2019-000917-S (to N.C.P.) and the “Centro de Investigación Biomédica en Red de Salud Mental-CIBERSAM” (CB/07/09/0033 and CB/07/09/0006). |
| Databáze: | OpenAIRE |
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