The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1
| Autor: | Karen van der Meulen, Ines Zarak, Annelies P. Vandekerckhove, Kathlyn Laval, Hossein Bannazadeh Baghi, Jing Zhao, Jolien Van Cleemput, Katrien C K Poelaert, Annick Gryspeerdt, Barbara Garré, Haileleul N Dubale, Eline Van Crombrugge, Hans Nauwynck |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
040301 veterinary sciences viruses therapies lcsh:QR1-502 Equine Herpesvirus type 1 Pseudorabies Review Microbiology lcsh:Microbiology Virus 0403 veterinary science Pathogenesis 03 medical and health sciences Immune system prevention Medicine Equine herpesvirus type 1 Veterinary Sciences immune evasion 030304 developmental biology 0303 health sciences biology business.industry pathogenesis Biology and Life Sciences Outbreak 04 agricultural and veterinary sciences biology.organism_classification Drug development Blood circulation Immunology business |
| Zdroj: | Frontiers in Microbiology, Vol 12 (2021) FRONTIERS IN MICROBIOLOGY Frontiers in Microbiology |
| ISSN: | 1664-302X |
| DOI: | 10.3389/fmicb.2021.662686 |
| Popis: | Equine herpesvirus type 1 (EHV-1) is an alphaherpesvirus related to pseudorabies virus (PRV) and varicella-zoster virus (VZV). This virus is one of the major pathogens affecting horses worldwide. EHV-1 is responsible for respiratory disorders, abortion, neonatal foal death and equine herpes myeloencephalopathy (EHM). Over the last decade, EHV-1 has received growing attention due to the frequent outbreaks of abortions and/or EHM causing serious economical losses to the horse industry worldwide. To date, there are no effective antiviral drugs and current vaccines do not provide full protection against EHV-1-associated diseases. Therefore, there is an urgent need to gain a better understanding of the pathogenesis of EHV-1 in order to develop effective therapies. The main objective of this review is to provide state-of-the-art information on the pathogenesis of EHV-1. We also highlight recent findings on EHV-1 immune evasive strategies at the level of the upper respiratory tract, blood circulation and endothelium of target organs allowing the virus to disseminate undetected in the host. Finally, we discuss novel approaches for drug development based on our current knowledge of the pathogenesis of EHV-1. |
| Databáze: | OpenAIRE |
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