Unilateral neck irradiation for well-lateralized oropharyngeal cancer
| Autor: | Peter van Rooij, Peter C. Levendag, Abrahim Al-Mamgani, D. Fransen |
|---|---|
| Přispěvatelé: | Radiotherapy, Hematology |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty law.invention SDG 3 - Good Health and Well-being Randomized controlled trial law medicine Humans Radiology Nuclear Medicine and imaging Feeding tube Aged Aged 80 and over Lymphatic Irradiation Soft palate business.industry Head and neck cancer Cancer Hematology Middle Aged medicine.disease Dysphagia Surgery Oropharyngeal Neoplasms stomatognathic diseases medicine.anatomical_structure Oncology Toxicity Tonsillar fossa Female Radiotherapy Intensity-Modulated medicine.symptom business |
| Zdroj: | Radiotherapy and Oncology, 106(1), 69-73. Elsevier Ireland Ltd |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2012.12.006 |
| Popis: | Background and purpose To investigate the impact of unilateral neck irradiation (UNI) of well-lateralized oropharyngeal cancer (OPC) on outcome and toxicity. Materials and methods Unilateral neck IMRT was applied to 185 consecutive patients with well-lateralized OPC (restricted to tonsillar fossa, soft palate with at least 1cm from midline or lateral pharyngeal wall). Endpoints were regional control (RC), local control (LC), disease-free survival (DFS), overall survival (OS), and toxicity. Results Six regional failures were reported (3.2%); 2 were contralateral (1.1%). The 5-year Kaplan–Meier estimates of RC, LC, DFS, and OS were 96%, 91%, 84%, and 70%, respectively. Feeding tube was given to 11.3%. Chemotherapy was significantly predictive for toxicity. However, no patient was still feeding tube dependent 6weeks after treatment. Overall grade 3 late toxicity was 2.2%. Grade 3 xerostomia was reported in only 1 patient while no patient developed grade 3 dysphagia. Conclusion This largest study on unilateral neck IMRT for well-lateralized OPC showed excellent outcome and favorable toxicity profile. Given the increasing incidence of OPC, especially among younger patients, and the favorable results reported in the current study and by other investigators, expanding the indications for UNI still needs to be further investigated in prospective, preferably, randomized trials. |
| Databáze: | OpenAIRE |
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