External quality assessment of patient HLA-B*57:01 testing prior to abacavir prescription

Autor:	S. Corbin, C. Darke
Rok vydání:	2014
Předmět:	Quality Control medicine.medical_specialty Anti-HIV Agents Immunology Human leukocyte antigen Immunogenetics Polymerase Chain Reaction Sensitivity and Specificity Drug Hypersensitivity Acquired immunodeficiency syndrome (AIDS) Abacavir Internal medicine External quality assessment Genetics medicine Humans Genetic Testing Medical prescription Molecular Biology Alleles Genetics (clinical) business.industry Histocompatibility Testing Reproducibility of Results General Medicine medicine.disease Dideoxynucleosides HLA-B Histocompatibility HLA-B Antigens business medicine.drug
Zdroj:	International Journal of Immunogenetics. 41:277-280
ISSN:	1744-3121
DOI:	10.1111/iji.12122
Popis:	Summary Hypersensitivity reactions to the drug abacavir are strongly associated with possession of HLA-B*57:01. Hence, patients with HIV/AIDS who may be prescribed abacavir should be tested for this HLA allele and the drug withheld from those that possess B*57:01. The UK National External Quality Assessment Service for Histocompatibility and Immunogenetics has operated a scheme for B*57:01 testing since 2008 which, in 2013, involved 47 participants from 12 countries. A total of 24 B*57:01-positive, 2 B*57:03-positive and 22 B*57-negative blood samples (including 2 B*58 samples) were distributed to between 28 and 47 laboratories each year over 6 years. Participants, who were unaware of the samples' HLA types, tested and reported on their B*57/B*57:01 status. A total of 1868 reports were assessed over the 6 years. Of the 880 reports on B*57:01 samples, 93.4% were correctly assigned as B*57:01, 2.8% were assigned as groups of B*57 alleles including B*57:01, and 3.3% were reported as B*57 positive only. Over the 6 years, there were four (0.46%) false B*57:01 negative reports. All the B*57:03-positive and B*57-negative samples, involving 72 and 916 assignments, respectively, were essentially reported as B*57:01 negative. Thus, there were no false B57:01 positive assignments. The reporting of B*57:01 status over the last 3 years of the scheme was 99.8% sensitive and 100% specific. Over the last year, it was 100% sensitive and 100% specific.
Databáze:	OpenAIRE
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