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The development of neurodegenerative diseases plays a critical role by the microbiota-gut-brain axis (GBA). It is owing to dysbiosis of the intestinal microbiome causing a significant alteration in the gut microbiota of Alzheimer's disease (AD) patients followed by neuroinflammatory processes. Thus, AD beginning in the gut is closely related to the imbalance of gut microbiota, hence a multi-domain approach to reduce it by exerting positive effects on the gut microbiota is needed. In one such example, tyrosine-based short peptide amphiphile (sPA), was used to synthesize antibacterial AgNPs-sPA nanostructures. Such nanostructures showed high biocompatibility and low cytotoxicity, therefore, work as a model drug delivery agent for addressing local bacterial infections and may have potential therapeutic value for the treatment of microbiota-triggered progression of neurodegenerative diseases. |
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