Autoimmune thyreoiditis in childhood – epidemiology, clinical and laboratory findings in 61 patients
| Autor: | M. Ruschenburg, Christian L. Roth, P. Stubbe, H. Zappel, Max Lakomek, M. Scortea, Wolfgang Becker |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Thyroid nodules endocrine system medicine.medical_specialty Goiter Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin 030209 endocrinology & metabolism Iodide Peroxidase Thyroglobulin Gastroenterology Thyroiditis Autoimmune thyroiditis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Epidemiology Internal Medicine Humans Medicine Euthyroid 030212 general & internal medicine Child Autoantibodies Sex Characteristics business.industry Thyroid Thyroiditis Autoimmune General Medicine medicine.disease Anti-thyroid autoantibodies 3. Good health Thyroxine medicine.anatomical_structure Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 105:66-69 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1211937 |
| Popis: | Autoimmune thyroiditis (AT) is the most common cause of nonendemic goiter and acquired hypothyroidism in children and adolescents. In 61 patients AT was diagnosed following clinical, ultrasonographic, biochemical and cytological examinations. Girls were more often affected than boys, the female/male ratio in our patients was 9:1. Clinically the vast majority of patients had a goiter. Approximately half of the patients were euthyroid (n = 29). In the other patients hyperthyrotropinaemia (n = 16), hypothyroidism (n = 9) and hyperthyroidism (n = 7) were evident. Thyroid microsomal and peroxidase antibodies were elevated in most of the patients, while thyroglobin antibodies were less frequently elevated. As AT without detectable thyroid antibodies can occur, a fine-needle aspiration cytology of the thyroid is important in nontypical cases. This type of cytologic examination should also be considered in patients with euthyroid nonendemic goiter, thyroid nodules and hyperthyroid goiter. |
| Databáze: | OpenAIRE |
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