Modulation of growth hormone receptor abundance and function: roles for the ubiquitin–proteasome system
| Autor: | Serge Y. Fuchs, Stuart J. Frank |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Proteasome Endopeptidase Complex
Growth hormone receptor Biology GHR Article 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Ubiquitin Animals Humans Tyrosine Growth hormone Molecular Biology 030304 developmental biology Insulin-like growth factor 1 receptor 0303 health sciences Proteasome Ubiquitination Receptors Somatotropin Biochemistry Hormone receptor Downregulation biology.protein Molecular Medicine Signal transduction 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1782:785-794 |
| ISSN: | 0925-4439 |
| Popis: | Growth hormone plays an important role in regulating numerous functions in vertebrates. Several pathways that negatively regulate the magnitude and duration of its signaling (including expression of tyrosine phosphatases, SOCS and PIAS proteins) are shared between signaling induced by growth hormone itself and by other cytokines. Here we overview downregulation of the growth hormone receptor as the most specific and potent mechanism of restricting cellular responses to growth hormone and analyze the role of several proteolytic systems and, specifically, ubiquitin-dependent pathways in this regulation. |
| Databáze: | OpenAIRE |
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