The Role of Autophagy in Intracellular Pathogen Nutrient Acquisition
| Autor: | Shaun Steele, Thomas H. Kawula, Jason Brunton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
nutrient acquisition Immunology lcsh:QR1-502 Review Virus Physiological Phenomena Biology Bacterial Physiological Phenomena Microbiology lcsh:Microbiology Xenophagy Autophagy Animals Humans Immune Evasion Host (biology) Intracellular parasite Entry into host Cell biology Infectious Diseases Eukaryotic Cells intracellular pathogens Host-Pathogen Interactions Intracellular |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 5 (2015) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2015.00051/full |
| Popis: | Following entry into host cells intracellular pathogens must simultaneously evade innate host defense mechanisms and acquire energy and anabolic substrates from the nutrient-limited intracellular environment. Most of the potential intracellular nutrient sources are stored within complex macromolecules that are not immediately accessible by intracellular pathogens. To obtain nutrients for proliferation, intracellular pathogens must compete with the host cell for newly-imported simple nutrients or degrade host nutrient storage structures into their constituent components (fatty acids, carbohydrates, and amino acids). It is becoming increasingly evident that intracellular pathogens have evolved a wide variety of strategies to accomplish this task. One recurrent microbial strategy is to exploit host degradative processes that break down host macromolecules into simple nutrients that the microbe can use. Herein we focus on how a subset of bacterial, viral, and eukaryotic pathogens leverage the host process of autophagy to acquire nutrients that support their growth within infected cells. |
| Databáze: | OpenAIRE |
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