Large and giant pituitary adenoma resection by microscopic trans-sphenoidal surgery: Surgical outcomes and complications in 123 consecutive patients
| Autor: | Jinzhang Sun, Bing Zhao, Mohan Karki, Chandra Prakash Yadav |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Cerebrospinal Fluid Rhinorrhea Endocrine Surgical Procedures Resection Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Pituitary adenoma Physiology (medical) Humans Medicine Pituitary Neoplasms Csf leakage Trans sphenoidal Aged Retrospective Studies business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Gross Total Resection Surgery Tumor recurrence Treatment Outcome Neurology 030220 oncology & carcinogenesis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Neuroscience. 44:310-314 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2017.07.015 |
| Popis: | To evaluate surgical outcomes and complications of patients who underwent microscopic trans-sphenoidal surgery (MTS) for large and giant pituitary adenomas (PAs). A retrospective study of electively operated cases of PA over a six year period was performed. Surgical outcomes and complications of 64 patients with large PAs (≥3cm) and 59 patients with giant PAs (>4cm), who underwent MTS at same period, were reviewed. Medical reports of all selected patients were assessed to collect demographic information such as age, sex, clinical symptoms, PA size, the extent of PA extension and resection, outcomes and complications. Patients with large PAs had improvement in visual improvement (78.1%; 50/64), gross total resection (84.4%; 54/64) compared to patients with giant PAs who had improvement in visual (71.2%; 42/59) and gross total resection (74.6%; 44/59). The rate of CSF leakage was 7.8% and 23.7% for large and giant PAs (p=0.0399). After a mean follow-up period of 40.8 (6-75) months, 10 (15.6%) patients with large PAs experienced tumor recurrence, while 2 giant PA patients (3.4%) experienced tumor recurrence after a mean follow-up period of 40.6 (3-70) months (p=0.0314). Resection of both large and giant pituitary adenomas by microscopic trans-sphenoidal surgery may be safe and effective surgical technique with low morbidity and mortality. |
| Databáze: | OpenAIRE |
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