Clinical, histopathological characteristics and immunohistochemical findings in lichen planus pigmentosus
| Autor: | C S Jayaprakash, Teena Ramesh Mathanda, Ramesh M Bhat, Sukumar Dandakeri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Lichen planus pigmentosus lichen planus pigmentosus Dermatology CD4+ 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine lcsh:Dermatology Outpatient clinic Prospective cohort study Pathological CD68 medicine.diagnostic_test business.industry Histology lcsh:RL1-803 CD8+ CD45RO (UCHL-1) 030220 oncology & carcinogenesis Skin biopsy immunohistochemistry Immunohistochemistry Original Article business |
| Zdroj: | Indian Journal of Dermatology, Vol 62, Iss 6, Pp 504-509 (2017) Indian Journal of Dermatology |
| ISSN: | 1998-3611 0019-5154 |
| Popis: | Background: Lichen planus pigmentosus (LPP), a rare variant of lichen planus, is reported in various ethnic groups, more often from the Indian subcontinent and the Middle East. Aims: Although the condition is encountered quite often by dermatologists of this region, the data on the clinical, pathological, and immunohistochemical (IHC) aspects of LPP are limited. This prospective study is aimed towards filling this lacuna. Materials and Methods: Data were collected from thirty clinically diagnosed cases of LPP who presented to the dermatology outpatient department. Skin biopsy and blood investigations were conducted and the specimens were further analyzed for their histopathological features and IHC staining for CD4+, CD8+ T-lymphocyte subsets along with CD45RO (UCHL-1), and CD68. The results were statistically analyzed. Results: The study showed a female preponderance (56.7%). Photo aggravation as a precipitating cause was seen in 40% of the individuals. The lesions with duration |
| Databáze: | OpenAIRE |
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