Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
| Autor: | Vitor Costa Fabris, Ana Luiza Maia, Mirian Romitti, Patricia Klarmann Ziegelmann, Poli Mara Spritzer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Endocrinology Diabetes and Metabolism MEDLINE 030209 endocrinology & metabolism Autoimmune thyroid disease lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology systematic review Internal medicine Internal Medicine PCOS Endocrine system Medicine 030219 obstetrics & reproductive medicine lcsh:RC648-665 business.industry TSH Research Autoantibody nutritional and metabolic diseases Sciences bio-médicales et agricoles Polycystic ovary female genital diseases and pregnancy complications meta-analysis Meta-analysis Thyroid function autoimmune thyroid disease business Cohort study |
| Zdroj: | Endocrine Connections Endocrine Connections, Vol 7, Iss 11, Pp 1158-1167 (2018) Endocrine Connections, 7 (11 |
| ISSN: | 2049-3614 |
| Popis: | Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18-40% of PCOS women, depending on PCOS diagnostic criteria and ethnicity. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding the likelihood of women with PCOS also having AITD in comparison to a reference group of non-PCOS women. We systematically searched EMBASE and MEDLINE for non-interventional case control, cross-sectional, or cohort studies published until August 2017. The Ottawa-Newcastle Scale was used to assess the methodological quality of studies. Statistical meta-analysis was performed with R. Thirteen studies were selected for the present analysis, including 1,210 women diagnosed with PCOS and 987 healthy controls. AITD was observed in 26.03% and 9.72% of PCOS and control groups respectively. A significant association was detected between PCOS and chance of AITD (OR= 3.27, 95%CI 2.32-4.63). Notably, after geographical stratification, the higher risk of AITD in PCOS women persisted for Asians (OR= 4.56, 95%CI 2.47-8.43), Europeans (OR= 3.27, 95%CI 2.07-5.15), and South Americans (OR= 1.86, 95 %CI 1.05-3.29). AIDT is a frequent condition in PCOS patients, and might affect thyroid function. Thus, screening for thyroid function and thyroid-specific autoantibodies should be considered in patients with PCOS even in the absence of overt symptoms. This systematic review and meta-analysis is registered in PROSPERO under number CRD42017079676. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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