Pilot trial of digital breast tomosynthesis (3D mammography) for population‐based screening in BreastScreen Victoria
| Autor: | Petra Macaskill, David Taylor, Vicki Pridmore, Jill Evans, Michelle Clemson, Nehmat Houssami, Darren Lockie, Georgina Marr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Victoria Population Breast Neoplasms Pilot Projects 1117 Public Health and Health Services 03 medical and health sciences diagnostic techniques and procedures 0302 clinical medicine Breast cancer Interquartile range Neoplasms medicine Humans Mass Screening Mammography 1112 Oncology and Carcinogenesis Breast Prospective Studies 030212 general & internal medicine education Early Detection of Cancer Mass screening Aged Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Tomosynthesis Clinical trial Female Screen reading Radiology business |
| Zdroj: | Medical Journal of Australia |
| Popis: | Objectives To estimate detection measures for tomosynthesis and standard mammography; to assess the feasibility of using tomosynthesis in population-based screening for breast cancer. Design, setting Prospective pilot trial comparing tomosynthesis (with synthesised 2D images) and standard mammography screening of women attending Maroondah BreastScreen, a BreastScreen Victoria service in the eastern suburbs of Melbourne. Participants Women at least 40 years of age who presented for routine breast screening between 18 August 2017 and 8 November 2018. Main outcome measures Cancer detection rate (CDR); proportion of screens that led to recall for further assessment. Results 5018 tomosynthesis and 5166 standard mammography screens were undertaken in 10 146 women; 508 women (5.0% of screens) opted not to undergo tomosynthesis screening. With tomosynthesis, 49 cancers (40 invasive, 9 in situ) were detected (CDR, 9.8 [95% CI, 7.2-13] per 1000 screens); with standard mammography, 34 cancers (30 invasive, 4 in situ) were detected (CDR, 6.6 [95% CI, 4.6-9.2] per 1000 screens). The estimated difference in CDR was 3.2 more detections (95% CI, -0.32 to 6.8) per 1000 screens with tomosynthesis; the difference was greater for repeat screens and for women aged 60 years or more. The recall rate was greater for tomosynthesis (4.2%; 95% CI, 3.6-4.8%) than standard mammography (3.0%; 95% CI, 2.6-3.5%; estimated difference, 1.2%; 95% CI, 0.46-1.9%). The median screen reading time for tomosynthesis was 67 seconds (interquartile range [IQR] 46-105 seconds); for standard mammography, 16 seconds (IQR, 10-29 seconds). Conclusions Breast cancer detection, recall for assessment, and screen reading time were each higher for tomosynthesis than for standard mammography. Our preliminary findings could form the basis of a large scale comparative evaluation of tomosynthesis and standard mammography for breast screening in Australia. Trial registration Australian New Zealand Clinical Trials Registry, ACTRN12617000947303. |
| Databáze: | OpenAIRE |
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