Chronic heart failure: a look through the rear view mirror
| Autor: | Eugene Braunwald |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Heart Failure
Male medicine.medical_specialty Qrs prolongation Framingham Risk Score Aldosterone business.industry medicine.medical_treatment Cardiac resynchronization therapy medicine.disease chemistry.chemical_compound Clinical research chemistry Internal medicine Heart failure medicine Cardiology Humans Female Cardiology and Cardiovascular Medicine business Intensive care medicine Angiotensin II Type I Receptor Blockers Developed country |
| Zdroj: | European Heart Journal. 34:1391-1392 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehs363 |
| Popis: | This editorial refers to ‘Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies’, by S.J. Pocock et al., doi:10.1093/eurheartj/ehs337 Heart failure is now the most common condition that leads to hospital admission in industrialized nations. Although the overall prognosis for patients with chronic heart failure is still gloomy, and similar to that of many of the most common forms of cancer,1 a combination of pre-clinical and clinical research conducted over the past 25 years has led to five significant advances, each of which has received a IA recommendation in the European Society of Cardiology Guidelines for the treatment of heart failure with reduced ejection fraction.2 These advances, well known to cardiologists, are: (i) blockers of the renin–angiotensin system [angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type I receptor blockers (ARBs)]; (ii) beta-adrenergic blockers; (iii) aldosterone antagonists; (iv) implantation of cardioverter-defibrillators; and (v) the application of cardiac resynchronization therapy in patients with QRS prolongation. Each has been shown to reduce mortality in patients with heart failure. As a consequence, the cumulative benefits of these therapies has improved the prognosis in these patients quite substantially.3 The development of a management plan for individual patients with heart failure (as is the case with many conditions) requires an assessment of prognosis. This has been a challenging task in patients with chronic heart failure. A number of risk scores have been established since 2003 to … |
| Databáze: | OpenAIRE |
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